Evidence map›Paper›PMID 27975098›Full record

ArticleThrombosis and haemostasis2017

Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia.

Andrea T Obi, Elizabeth Andraska, Yogendra Kanthi, Chase W Kessinger, Megan Elfline, Cathy Luke, Teruna J Siahaan, Farouc A Jaffer, Thomas W Wakefield, Peter K Henke

Open access · bronzeAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  12. Immune cell-mediated venous thrombus resolution.Research and practice in thrombosis and haemostasis · 2023
    Review
  13. Article
  14. Review
  15. P- and E- selectin in venous thrombosis and non-venous pathologies.Journal of thrombosis and haemostasis : JTH · 2022
    Review
  16. Article
  17. Review
  18. [LPS stimulating neutrophils firmly adhered to ICAM-1 to form extracellular traps depends on integrin Mac-1 and cytoskeletal proteins].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Andrea T Obi
Elizabeth Andraska
Yogendra Kanthi
Chase W Kessinger
Megan Elfline
Cathy Luke
Teruna J Siahaan
Farouc A Jaffer
Thomas W Wakefield
Peter K HenkePeter K. Henke, MD, University of Michigan Health System, 1500 E. Medical Center Drive, Cardiovascular Center - 5463, Ann Arbor, MI 48109-5867, USA, Tel.: +1 734 763 0250, Fax: +1 734 647 9867, E-mail: henke@umich.edu.
University of Michigan–Ann Arbor · USHarvard University · USMassachusetts General Hospital · USUniversity of Kansas · US

Funding

TRAINING IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007853 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David J. Pinsky · 1996 to 2026
$11.6M
Thrombotic/Fibrinolytic Balance in Cardiac Transplant VasculopathyP01HL089407 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, DANIEL A · 2008 to 2012
$7.9M
NIRF-OFDI of Inflammation in Atheroma Progression and Stent ComplicationsR01HL122388 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2015 to 2018
$2.1M
Vascular Surgery: Research Training in Vascular BiologyT32HL076123 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K, WAKEFIELD, THOMAS WILLIAM · 2004 to 2019
$1.9M
Vein Wall Fibrotic Injury After DVT is SLC-CCR7 DependentR01HL092129 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2009 to 2012
$1.5M
CD39 in Vein Graft ArterializationK08HL131993 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KANTHI, YOGENDRA · 2016 to 2020
$837k
NHLBI NIH HHS K08 HL131993NHLBI NIH HHS L30 HL115712NHLBI NIH HHS L30 HL129373NHLBI NIH HHS P01 HL089407NHLBI NIH HHS R01 HL092129NHLBI NIH HHS R01 HL122388NHLBI NIH HHS T32 HL007853NHLBI NIH HHS T32 HL076123
6 · The paper itself

Abstract

Venous thromboembolism is a major cause of death during and immediately post-sepsis. Venous thrombosis (VT) is mediated by cell adhesion molecules and leukocytes, including neutrophil extracellular traps (NETs). Sepsis, or experimentally, endotoxaemia, shares similar characteristics and is modulated via toll like receptor 4 (TLR4). This study was undertaken to determine if endotoxaemia potentiates early stasis thrombogenesis, and secondarily to determine the role of VT TLR4, ICAM-1 and neutrophils (PMNs). Wild-type (WT), ICAM-1

Indexed as

Blood CoagulationAnimalsBlood PlateletsCell AdhesionDisease Models, AnimalEndotoxemiaFactor VIIIFibrinogenIntercellular Adhesion Molecule-1Leukocyte RollingMaleMice, Inbred C57BLMice, KnockoutNeutropeniaNeutrophilsSignal TransductionFactor VIIIFibrinogenIcam1 protein, mouseIntercellular Adhesion Molecule-1Tlr4 protein, mouseToll-Like Receptor 4cellular adhesion moleculesICAM-1LPSsepsisTLR4venous thromboembolismvenous thrombosis

Identifiers

PMID27975098
PMCPMC5436925
OpenAlexW2566457427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.