Evidence map›Paper›PMID 27974843›Full record

ReviewNature reviews. Neuroscience2016

Structural plasticity and reorganisation in chronic pain.

Rohini Kuner, Herta Flor

Erratum issued Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06417528 (Chronic Postsurgical Pain), which is not on this map. Cited by 254 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06417528 unknown statusnot on this mapstarted 2022, after this paper: background citation

Chronic Postsurgical Pain: Multivariate Prediction Model

TypeobservationalSponsorSocieta Italiana Anestesia Analgesia Rianimazione e Terapia IntensivaRan2022 to 2025Enrolled1,500ConditionsPost Surgical Pain, Post Operative Pain, Postoperative Pain, ChronicArmsChronic Post Surgery Pain (CPSP)
3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
  7. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
  8. Article
  9. Effects ofPain reports · 2026
    Article
  10. Peripheral NabioRxiv : the preprint server for biology · 2026
    Article
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  16. Article
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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rohini KunerInstitute of Pharmacology, Heidelberg University.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, and Department of Psychology, University of Mannheim, J 5, 68159 Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional plasticity in neural circuits of pain have provided mechanistic insights and linked various modulatory factors to a change in perception and behaviour. However, plasticity also occurs in the context of structural remodelling and reorganisation of synapses, cells and circuits, potentially contributing to the long-term nature of chronic pain. This Review discusses maladaptive structural plasticity in neural circuits of pain, spanning multiple anatomical and spatial scales in animal models and human patients, and addresses key questions on structure-function relationships.

Indexed as

NeuroimagingAnimalsChronic PainHumansNerve NetNeuronal PlasticityNeuronsSynapses

Identifiers

PMID27974843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.