Evidence map›Paper›PMID 27974841›Full record

ReviewNature reviews. Neuroscience2016

Towards a mechanistic understanding of the human subcortex.

Birte U Forstmann, Gilles de Hollander, Leendert van Maanen, Anneke Alkemade, Max C Keuken

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  10. Joint models reveal human subcortical underpinnings of choice and learning behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  12. Locus coeruleus-related insula activation supports implicit learning.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Birte U ForstmannAmsterdam Brain and Cognition Centre, University of Amsterdam, Nieuwe Achtergracht 129B, 1018 WT Amsterdam, The Netherlands; and at the Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Gilles de HollanderAmsterdam Brain and Cognition Centre, University of Amsterdam, Nieuwe Achtergracht 129B, 1018 WT Amsterdam, The Netherlands; and at the Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Leendert van MaanenAmsterdam Brain and Cognition Centre, University of Amsterdam, Nieuwe Achtergracht 129B, 1018 WT Amsterdam, The Netherlands; and at the Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Anneke AlkemadeAmsterdam Brain and Cognition Centre, University of Amsterdam, Nieuwe Achtergracht 129B, 1018 WT Amsterdam, The Netherlands; and at the Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Max C KeukenAmsterdam Brain and Cognition Centre, University of Amsterdam, Nieuwe Achtergracht 129B, 1018 WT Amsterdam, The Netherlands; and at the Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human subcortex is a densely populated part of the brain, of which only 7% of the individual structures are depicted in standard MRI atlases. In vivo MRI of the subcortex is challenging owing to its anatomical complexity and its deep location in the brain. The technical advances that are needed to reliably uncover this 'terra incognita' call for an interdisciplinary human neuroanatomical approach. We discuss the emerging methods that could be used in such an approach and the incorporation of the data that are generated from these methods into model-based cognitive neuroscience frameworks.

Indexed as

Brain MappingAnimalsArtificial IntelligenceBrainCognitionHumansImage Processing, Computer-AssistedMagnetic Resonance Imaging

Identifiers

PMID27974841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.