ArticleScientific reports2016
Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- From dog bite to dialysis: complement-mediated haemolytic uraemic syndrome .BMJ case reports · 2026Article
- Fastidious or rarely isolated gram-negative rods with a particular focus onClinical microbiology reviews · 2025Review
- Capnocytophaga canimorsus from Dog Saliva Exposure Causing Severe Sepsis in a Healthy Adult: A Case Report.The American journal of case reports · 2025Article
- Septic shock due toJournal of intensive medicine · 2024Article
- Article
- Lethal Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an asplenic patient.BMC infectious diseases · 2022Article
- Cellulitis and transient bacteremia byAccess microbiology · 2022Article
- A case of septic arthritis caused byAccess microbiology · 2022Article
- [Sepsis caused by Capnocytophaga canimorsus in an immunocompetent patient].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Article
- Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Observational
- Complete Lipopolysaccharide ofFrontiers in cellular and infection microbiology · 2022Article
- The use of eculizumab in Capnocytophaga canimorsus associated thrombotic microangiopathy: a case report.BMC infectious diseases · 2021Article
- Integrative Genomics Sheds Light on Evolutionary Forces Shaping the Acidithiobacillia Class Acidophilic Lifestyle.Frontiers in microbiology · 2021Article
- Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000-2017.Emerging infectious diseases · 2018Article
- Capsular serovars of virulent Capnocytophaga canimorsus are shared by the closely related species C. canis and C. cynodegmi.Emerging microbes & infections · 2018Article
- Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing.Journal of clinical microbiology · 2017Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capnocytophaga canimorsus is a dog's and cat's oral commensal which can cause fatal human infections upon bites or scratches. Infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. Here we present the discovery of a polysaccharide capsule (CPS) at the surface of C. canimorsus 5 (Cc5), a strain isolated from a fulminant septicaemia. We provide genetic and chemical data showing that this capsule is related to the lipooligosaccharide (LOS) and probably composed of the same polysaccharide units. A CPS was also found in nine out of nine other strains of C. canimorsus. In addition, the genomes of three of these strains, sequenced previously, contain genes similar to those encoding CPS biosynthesis in Cc5. Thus, the presence of a CPS is likely to be a common property of C. canimorsus. The CPS and not the LOS confers protection against the bactericidal effect of human serum and phagocytosis by macrophages. An antiserum raised against the capsule increased the killing of C. canimorsus by human serum thus showing that anti-capsule antibodies have a protective role. These findings provide a new major element in the understanding of the pathogenesis of C. canimorsus.
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