Evidence map›Paper›PMID 27974821›Full record

Trial reportScientific reports2016

Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy.

Diane E Halliwell, Maria Kyrgiou, Anita Mitra, Ilkka Kalliala, Evangelos Paraskevaidis, Georgios Theophilou, Pierre L Martin-Hirsch, Francis L Martin

Open access · goldAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Diane E HalliwellCentre for Biophotonics, LEC, Lancaster University, Lancaster, UK.
Maria KyrgiouInstitute of Reproductive and Developmental Biology, Department of Surgery &Cancer, Faculty of Medicine, Imperial College, London, UK.
Anita MitraInstitute of Reproductive and Developmental Biology, Department of Surgery &Cancer, Faculty of Medicine, Imperial College, London, UK.
Ilkka KallialaInstitute of Reproductive and Developmental Biology, Department of Surgery &Cancer, Faculty of Medicine, Imperial College, London, UK.
Evangelos ParaskevaidisDepartment of Obstetrics and Gynaecology, University of Ioannina, Ioannina, Greece.
Georgios TheophilouSt James Hospital, Leeds, West Yorkshire, UK.
Pierre L Martin-HirschDepartment of Obstetrics and Gynaecology, Lancashire Teaching Hospitals NHS Trust Foundation, Preston, UK.
Francis L MartinCentre for Biophotonics, LEC, Lancaster University, Lancaster, UK.
Imperial College London · GBLancaster University · GBImperial College Healthcare NHS Trust · GBLancashire Teaching Hospitals NHS Foundation Trust · GBSt James's University Hospital · GBUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Local excisional treatment for cervical intra-epithelial neoplasia (CIN) is linked to significant adverse sequelae including preterm birth, with cone depth and radicality of treatment correlating to the frequency and severity of adverse events. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy can detect underlying cervical disease more accurately than conventional cytology. The chemical profile of cells pre- and post-treatment may differ as a result of altered biochemical processes due to excision, or treatment of the disease. Since pre-treatment cervical length varies amongst women, the percentage of cervix excised may correlate more accurately to risk than absolute dimensions. We show that treatment for CIN significantly alters the biochemistry of the cervix, compared with women who have not had treatment; this is due to the removal of cervical tissue rather than the removal of the disease. However, the spectra do not seem to correlate to the cone depth or proportion of cervical length excised. Future research should aim to explore the impact of treatment in a larger cohort.

Indexed as

AdolescentAdultCervix UteriFemaleHumansMaleMiddle AgedSpectroscopy, Fourier Transform InfraredUterine Cervical Dysplasia

Identifiers

PMID27974821
PMCPMC5156919
OpenAlexW2567628387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.