Evidence map›Paper›PMID 27974793›Full record

ArticleNature2017

Targeting metastasis-initiating cells through the fatty acid receptor CD36.

Gloria Pascual, Alexandra Avgustinova, Stefania Mejetta, Mercè Martín, Andrés Castellanos, Camille Stephan-Otto Attolini, Antoni Berenguer, Neus Prats, Agustí Toll, Juan Antonio Hueto and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 902 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
902citing papers in PubMed, 1 pooled it
39.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

902 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,386 citations in OpenAlex.

  1. Pooled it
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  12. Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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842 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Gloria PascualInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Alexandra AvgustinovaInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Stefania MejettaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.
Mercè MartínInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Andrés CastellanosInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Camille Stephan-Otto AttoliniInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Antoni BerenguerInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Neus PratsInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Agustí TollIMIM, Department of Dermatology, Hospital del Mar, 08003 Barcelona.
Juan Antonio HuetoVall D´Hebron Hospital, Barcelona, Department of Oral and Maxillofacial Surgery, Universitat Autònoma de Barcelona, Barcelona 08035 Spain.
Coro BescósVall D´Hebron Hospital, Barcelona, Department of Oral and Maxillofacial Surgery, Universitat Autònoma de Barcelona, Barcelona 08035 Spain.
Luciano Di CroceCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.
Salvador Aznar BenitahInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Institute for Research in Biomedicine · ESUniversitat Autònoma de Barcelona · ESCentre for Genomic Regulation · ESInstitució Catalana de Recerca i Estudis Avançats · ESMunicipal Institute for Medical Research · ES

Funding

Worldwide Cancer Research 13-1064
6 · The paper itself

Abstract

The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44

Indexed as

AnimalsAntibodies, NeutralizingCD36 AntigensCell ProliferationDiet, High-FatDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticHumansHyaluronan ReceptorsLipid MetabolismLymphatic MetastasisMaleMiceMouth NeoplasmsNeoplasm MetastasisAntibodies, NeutralizingCD36 AntigensHyaluronan ReceptorsPalmitic Acid

Identifiers

PMID27974793
OpenAlexW2560396365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.