ArticleMolecular biology of the cell2017
Fidgetin regulates cultured astrocyte migration by severing tyrosinated microtubules at the leading edge.
Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- FIGNL1 Promotes Hepatocellular Carcinoma FormationCurrent gene therapy · 2024Article
- Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury.Neural regeneration research · 2023Article
- Kif15 deficiency contributes to depression-like behavior in mice.Metabolic brain disease · 2023Article
- Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury.CNS neuroscience & therapeutics · 2023Article
- Pulmonary Toxicity and Proteomic Analysis in Bronchoalveolar Lavage Fluids and Lungs of Rats Exposed to Copper Oxide Nanoparticles.International journal of molecular sciences · 2022Article
- Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury.Neural regeneration research · 2022Article
- Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing: implications for neurodegeneration mechanisms.Neural regeneration research · 2022Article
- Transcription of the Envelope Protein by 1-L Protein-RNA Recognition Code Leads to Genes/Proteins That Are Relevant to the SARS-CoV-2 Life Cycle and Pathogenesis.Current issues in molecular biology · 2022Article
- The Role of Spastin in Axon Biology.Frontiers in cell and developmental biology · 2022Review
- Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.JCI insight · 2021Article
- FIGNL1 promotes non‑small cell lung cancer cell proliferation.International journal of oncology · 2021Observational
- A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule‑severing function.Molecular medicine reports · 2020Article
- Fidgetin as a potential prognostic biomarker for hepatocellular carcinoma.International journal of medical sciences · 2020Article
- Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development.Frontiers in cell and developmental biology · 2020Article
- Predicted Effects of Severing Enzymes on the Length Distribution and Total Mass of Microtubules.Biophysical journal · 2019Article
- Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.Cell research · 2019Article
- HMGB1 contributes to SASH1 methylation to attenuate astrocyte adhesion.Cell death & disease · 2019Article
- Differential Circular RNA Expression Profiles Following Spinal Cord Injury in Rats: A Temporal and Experimental Analysis.Frontiers in neuroscience · 2019Article
- Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish.Traffic (Copenhagen, Denmark) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubule (MT) organization is essential for many cellular events, including mitosis, migration, and cell polarity. Fidgetin (Fign), an ATP-dependent, MT-severing protein, contributes to the regulation of MT configuration by cutting and trimming MT polymers. Functions of Fign have been indicated in neurite outgrowth, mitosis, meiosis, and cellular migration. Here we focus on migration of astrocytes. We find that Fign plays an essential role in cultured astrocyte migration by preferentially targeting MTs (or regions of MTs) that are rich in tyrosinated tubulin, a marker for especially dynamic MTs or especially dynamic regions of MTs. Inhibition of cellular migration induced by Fign knockdown can be rescued with concomitant knockdown of kinesin-12, a motor protein best known for its role in mitosis. We propose a novel working model for MT reconfiguration underlying cellular migration elicited by the functional cooperation of two distinct MT-related proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.