Evidence map›Paper›PMID 27974622›Full record

ArticleRNA (New York, N.Y.)2017

The conserved SNARE SEC-22 localizes to late endosomes and negatively regulates RNA interference in

Yani Zhao, Benjamin T Holmgren, Andrea Hinas

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yani ZhaoDepartment of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.
Benjamin T HolmgrenDepartment of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.
Andrea HinasDepartment of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0002-9353-0742
Uppsala University · SE

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Small RNA pathways, including RNA interference (RNAi), play crucial roles in regulation of gene expression. Initially considered to be cytoplasmic, these processes have later been demonstrated to associate with membranes. For example, maturation of late endosomes/multivesicular bodies (MVBs) is required for efficient RNAi, whereas fusion of MVBs to lysosomes appears to reduce silencing efficiency. SNAREs (soluble

Indexed as

RNA InterferenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEndosomesGenes, ReporterLuminescent ProteinsLysosomesMembrane FusionProtein-Tyrosine KinasesRecombinant Fusion ProteinsRed Fluorescent ProteinRNA, Double-StrandedRNA, HelminthRNA, Small InterferingSNARE ProteinsCaenorhabditis elegans ProteinsLuminescent ProteinsProtein-Tyrosine KinasesRecombinant Fusion ProteinsRed Fluorescent ProteinRNA, Double-StrandedRNA, HelminthRNA, Small InterferingSEC-22 protein, C eleganssid-5 protein, C elegansSNARE ProteinsC. eleganslate endosomeRNAiSNARE

Identifiers

PMID27974622
PMCPMC5311485
OpenAlexW2564093803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.