Evidence map›Paper›PMID 27974621›Full record

ArticleRNA (New York, N.Y.)2017

Characterization of a TUTase/RNase complex required for

Ching-Jung Lin, Jiayu Wen, Fernando Bejarano, Fuqu Hu, Diane Bortolamiol-Becet, Lijuan Kan, Piero Sanfilippo, Shu Kondo, Eric C Lai

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. The biogenesis and regulation of animal microRNAs.Nature reviews. Molecular cell biology · 2025
    Review
  3. Article
  4. Regulation of RNA stability at the 3' end.Biological chemistry · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ching-Jung LinSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Jiayu WenSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Fernando BejaranoSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Fuqu HuSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Diane Bortolamiol-BecetSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Lijuan KanSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Piero SanfilippoSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA.
Shu KondoInvertebrate Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
Eric C LaiSloan-Kettering Institute, Department of Developmental Biology, New York, New York 10065, USA laie@mskcc.org.
Kettering University · USCornell University · USMemorial Sloan Kettering Cancer Center · USNational Institute of Genetics · JP

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Selective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8M
Mechanism and regulation of Hu family RNA binding proteins during neural alternative polyadenylationR01NS083833 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2014 to 2023
$5.4M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM083300NINDS NIH HHS R01 NS083833
6 · The paper itself

Abstract

Post-transcriptional regulatory strategies that involve coupling between terminal uridyltransferase (TUTase) and exoribonuclease enzymes have recently been characterized in diverse species. Of note, the 3' exoribonuclease Dis3L2 has received substantial attention as a factor that metabolizes uridylated substrates in contexts such as general mRNA degradation, turnover of specific miRNAs, and quality control of noncoding RNAs. To date, most studies of Dis3L2 have focused on fungi and mammalian cells. Here, we introduce

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsExoribonucleasesFemaleInfertility, FemaleInfertility, MaleMaleMutationRNA NucleotidyltransferasesRNA Processing, Post-TranscriptionalRNA, UntranslatedSpermatogenesisDrosophila ProteinsExoribonucleasesRNA NucleotidyltransferasesRNA, UntranslatedUTP-RNA uridylyltransferaseDrosophilaexoribonucleasespermatogenesisTUTase

Identifiers

PMID27974621
PMCPMC5311484
OpenAlexW2567715523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.