Evidence map›Paper›PMID 27974620›Full record

ArticleRNA (New York, N.Y.)2017

Will the circle be unbroken: specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of Gemin2.

Beate Schwer, Allen J Roth, Stewart Shuman

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. A unique mechanism of snRNP core assembly.Nature communications · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Beate SchwerMicrobiology and Immunology Department, Weill Cornell Medical College, New York, New York 10065, USA bschwer@med.cornell.edu s-shuman@ski.mskcc.org.
Allen J RothMicrobiology and Immunology Department, Weill Cornell Medical College, New York, New York 10065, USA.
Stewart ShumanMolecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA bschwer@med.cornell.edu s-shuman@ski.mskcc.org.
Cornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
mRNA Capping EnzymesR01GM052470 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHWER, BEATE, SHUMAN, STEWART H · 1995 to 2019
$9.9M
RNA caps and meiotic pre-mRNA splicingR01GM102961 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWER, BEATE · 2013 to 2016
$1.3M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM052470NIGMS NIH HHS R01 GM102961
6 · The paper itself

Abstract

A seven-subunit Sm protein ring assembles around specific U-rich RNA segments of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing. Using human snRNP crystal structures to guide mutagenesis in

Indexed as

RNA SplicingAmino Acid SequenceBinding SitesGene ExpressionGenes, LethalGenetic Complementation TestHumansMutationNerve Tissue ProteinsProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsProtein SubunitsRecombinant ProteinsRibonucleoproteins, Small NuclearBRR1 protein, S cerevisiaeGEMIN2 protein, humanNerve Tissue ProteinsProtein SubunitsRecombinant ProteinsRibonucleoproteins, Small NuclearRNA-Binding ProteinsRNA, Small NuclearSaccharomyces cerevisiae Proteins

Identifiers

PMID27974620
PMCPMC5311505
OpenAlexW2561395928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.