Evidence map›Paper›PMID 27974563›Full record

ArticleJournal of virology2017

Human CD4

Michael A Angelo, Alba Grifoni, Patrick H O'Rourke, John Sidney, Sinu Paul, Bjoern Peters, Aruna D de Silva, Elizabeth Phillips, Simon Mallal, Sean A Diehl and 5 more

Abstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Trial
  2. Article
  3. T Cell Responses During Dengue Infection.Current topics in microbiology and immunology · 2026
    Review
  4. Dengue and severe dengue.Clinical microbiology reviews · 2025
    Review
  5. CD4Vaccines · 2025
    Article
  6. Review
  7. Human T Cell Responses to Flavivirus Vaccines.European journal of immunology · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael A AngeloDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Alba GrifoniDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Patrick H O'RourkeDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
John SidneyDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Sinu PaulDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Bjoern PetersDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Aruna D de SilvaDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Elizabeth PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Simon MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Sean A DiehlUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
Beth D KirkpatrickUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
Stephen S WhiteheadNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Anna P DurbinJohns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Daniela WeiskopfDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA Daniela@lji.org.

Funding

Clinical Trials of Biodefense Vaccines (Dengue, West Nile Virus, TBEV)ZIAAI000987 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WHITEHEAD, STEPHEN · 2009 to 2025
$37.9M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2015 to 2019
$13.0M
NIAID NIH HHS HHSN272200900042CNIAID NIH HHS HHSN272201400045CNIGMS NIH HHS P50 GM115305
6 · The paper itself

Abstract

Dengue virus (DENV) is responsible for growing numbers of infections worldwide and has proven to be a significant challenge for vaccine development. We previously demonstrated that CD8

Indexed as

VaccinationAdolescentAdultAntibodies, ViralAntibody SpecificityCD4-Positive T-LymphocytesCells, CulturedDengueDengue VaccinesDengue VirusFemaleHLA AntigensHumansMaleMiddle AgedVaccines, AttenuatedAntibodies, ViralDengue VaccinesHLA AntigensVaccines, AttenuatedViral ProteinsCD4CD4+ T celldengue virusHLAlive attenuatedlive attenuated vaccineMHCT cellstetravalentTV005vaccines

Identifiers

PMID27974563
PMCPMC5309943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.