Evidence map›Paper›PMID 27974513›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2017

Bacterial Proteasomes: Mechanistic and Functional Insights.

Samuel H Becker, K Heran Darwin

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Plasticity in the structure and assembly of proteasomes.The Journal of biological chemistry · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Protein degradation by a component of the chaperonin-linked protease ClpP.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Review
  6. Article
  7. Review
  8. HtrAs are essential for the survival of the haloarchaeonApplied and environmental microbiology · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samuel H BeckerDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
K Heran DarwinDepartment of Microbiology, New York University School of Medicine, New York, New York, USA heran.darwin@med.nyu.edu.

Funding

INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
PROTEASOME-DEPENDENT DEGRADATION IN MYCOBACTERIUM TUBERCULOSISR01AI088075 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katerina Heran Darwin · 2011 to 2026
$6.5M
Virulence Regulation by the Mycobacterium Tuberculosis ProteasomeR01HL092774 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DARWIN, KATERINA HERAN · 2007 to 2017
$4.0M
NHLBI NIH HHS R01 HL092774NIAID NIH HHS R01 AI088075NIAID NIH HHS T32 AI007180
6 · The paper itself

Abstract

Regulated proteolysis is essential for the normal physiology of all organisms. While all eukaryotes and archaea use proteasomes for protein degradation, only certain orders of bacteria have proteasomes, whose functions are likely as diverse as the species that use them. In this review, we discuss the most recent developments in the understanding of how proteins are targeted to proteasomes for degradation, including ATP-dependent and -independent mechanisms, and the roles of proteasome-dependent degradation in protein quality control and the regulation of cellular physiology. Furthermore, we explore newly established functions of proteasome system accessory factors that function independently of proteolysis.

Indexed as

ProteolysisAdenosine TriphosphateArchaeaBacteriaBacterial ProteinsProteasome Endopeptidase ComplexAdenosine TriphosphateBacterial ProteinsProteasome Endopeptidase Complexproteasome

Identifiers

PMID27974513
PMCPMC5312241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.