Evidence map›Paper›PMID 27974468›Full record

ArticleThe Journal of biological chemistry2017

Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.

Lei Jia, Fan Yan, Wenfeng Cao, Zhengming Chen, Hong Zheng, Haixin Li, Yi Pan, Navneet Narula, Xiubao Ren, Hui Li and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  10. UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis.Journal of experimental & clinical cancer research : CR · 2022
    Article
  11. Review
  12. Article
  13. CUL4The American journal of pathology · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Lei JiaFrom the Department of Immunology, Key Laboratory of Cancer Immunology and Biotherapy.
Fan YanFrom the Department of Immunology, Key Laboratory of Cancer Immunology and Biotherapy.
Wenfeng CaoDepartment of Pathology, Key Laboratory of Tianjin Cancer Prevention and Treatment.
Zhengming ChenHealthcare Policy and Research, Weill Cornell Medical College, New York, New York 10065.
Hong ZhengDepartment of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, and.
Haixin LiDepartment of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, and.
Yi PanDepartment of Pathology, Key Laboratory of Tianjin Cancer Prevention and Treatment.
Navneet Narulathe Departments of Pathology and Laboratory Medicine and.
Xiubao RenFrom the Department of Immunology, Key Laboratory of Cancer Immunology and Biotherapy, rwziyi@yahoo.com.
Hui LiFrom the Department of Immunology, Key Laboratory of Cancer Immunology and Biotherapy, lihui@tjmuch.com.
Pengbo ZhouFrom the Department of Immunology, Key Laboratory of Cancer Immunology and Biotherapy, pez2001@med.cornell.edu.
Tianjin Medical University Cancer Institute and Hospital · CNCornell University · USPeking University · CNYahoo (Spain) · ES

Funding

Regulation of Nucleotide Excision Repair by ProteolysisR01CA098210 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2003 to 2013
$3.3M
Tumorigenic Role of the CUL4A Ubiquitin LigaseR01CA159925 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHIN, SANDRA, ZHOU, PENGBO · 2011 to 2015
$2.0M
Regulation of Nucleotide Excision Repair by ProteolysisR56CA098210 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2008 to 2008
$329k
NCI NIH HHS R01 CA098210NCI NIH HHS R01 CA159925NCI NIH HHS R56 CA098210
6 · The paper itself

Abstract

The

Indexed as

Cell Line, TumorCullin ProteinsHumansImmunohistochemistryLung NeoplasmsPrognosisReceptors, Interleukin-17SmokingSubstrate SpecificitySurvival AnalysisUbiquitin-Protein LigasesCUL4B protein, humanCullin ProteinsIL17RB protein, humanReceptors, Interleukin-17Ubiquitin-Protein Ligasescell signalingE3 ubiquitin ligaseimmunohistochemistrylung cancerprotein degradationubiquitinubiquitin ligase

Identifiers

PMID27974468
PMCPMC5314191
OpenAlexW2572210247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.