ReviewClinical microbiology reviews2017
The Human Ureaplasma Species as Causative Agents of Chorioamnionitis.
Review in Clinical microbiology reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05603624 (Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term), which is not on this map. Cited by 95 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term
Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- The microbiology of amniotic fluid sludge: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2026Pooled it
- Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000-2019).BMC public health · 2020Pooled it
- Trial
- Presumably recurrent Ureaplasma parvum infection in a female peritoneal dialysis patient: a case report and literature review.BMC nephrology · 2026Review
- Review
- Sex-specific outcomes following chorioamnionitis.Pediatric research · 2026Review
- Ureaplasma parvum and Ureaplasma urealyticum induce distinct types of inflammation in neonates and human epithelial cell models.Pediatric research · 2026Article
- The role of Ureaplasma in preterm lung disease: does species matter?Pediatric research · 2026Article
- Reconceptualizing chorioamnionitis as an immune-mediated inflammatory disorder at the maternal-fetal interface.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?Journal of neuroinflammation · 2026Review
- Comparative analysis of diagnostic kits for detectingPractical laboratory medicine · 2026Article
- Association between maternal cervical Ureaplasma urealyticum colonization and adverse perinatal outcomes: a prospective multicenter cohort study.BMC pregnancy and childbirth · 2026Article
- Development of a novel multi-epitope vaccine against Ureaplasma urealyticum infection through reverse vaccinology approach.Molecular diversity · 2026Article
- Ureaplasma-driven inhibition of the epithelial Na+ transport in fetal alveolar cells: A novel mechanism of Ureaplasma-mediated preterm lung disease.PLoS pathogens · 2025Article
- The placenta as a window into neonatal brain injury.Seminars in perinatology · 2025Review
- Real-Time PCR Test (Flora Select™) for Assessing the Effectiveness of Bacterial Vaginosis Treatment During Pregnancy.Microorganisms · 2025Article
- Study protocol: neonatal colonisation and infection withBMJ open · 2025Article
- The Impact of Intrauterine Devices on the Risk of Ureaplasma Species Overgrowth: A Review of the Literature.Cureus · 2025Review
- Molecular Mechanisms Underlying Inflammation in Early-Onset Neonatal Sepsis: A Systematic Review of Human Studies.Journal of clinical medicine · 2025Review
- Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human Ureaplasma species are the most frequently isolated microorganisms from the amniotic fluid and placentae of women who deliver preterm and are also associated with spontaneous abortions or miscarriages, neonatal respiratory diseases, and chorioamnionitis. Despite the fact that these microorganisms have been habitually found within placentae of pregnancies with chorioamnionitis, the role of Ureaplasma species as a causative agent has not been satisfactorily explained. There is also controversy surrounding their role in disease, particularly as not all women infected with Ureaplasma spp. develop chorioamnionitis. In this review, we provide evidence that Ureaplasma spp. are associated with diseases of pregnancy and discuss recent findings which demonstrate that Ureaplasma spp. are associated with chorioamnionitis, regardless of gestational age at the time of delivery. Here, we also discuss the proposed major virulence factors of Ureaplasma spp., with a focus on the multiple-banded antigen (MBA), which may facilitate modulation/alteration of the host immune response and potentially explain why only subpopulations of infected women experience adverse pregnancy outcomes. The information presented within this review confirms that Ureaplasma spp. are not simply "innocent bystanders" in disease and highlights that these microorganisms are an often underestimated pathogen of pregnancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.