ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Mechanisms of blood pressure salt sensitivity: new insights from mathematical modeling.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Predicting cardiac and renal responses to sacubitril/valsartan with a mathematical model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2025Article
- Aging and sex differences in salt sensitivity of blood pressure.Clinical science (London, England : 1979) · 2025Review
- Effect of low sodium and high potassium diet on lowering blood pressure and cardiovascular events.Clinical hypertension · 2024Review
- Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease.Frontiers in systems biology · 2024Article
- Modeling the renoprotective mechanisms of SGLT2 inhibition in hypertensive chronic kidney disease.Physiological reports · 2023Article
- Modeling the physiological roles of the heart and kidney in heart failure with preserved ejection fraction during baroreflex activation therapy.American journal of physiology. Heart and circulatory physiology · 2022Article
- Reducing Sodium Consumption in Mexico: A Strategy to Decrease the Morbidity and Mortality of Cardiovascular Diseases.Frontiers in public health · 2022Article
- Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: quantitative insights for precision medicine.iScience · 2021Article
- In silico trial of baroreflex activation therapy for the treatment of obesity-induced hypertension.PloS one · 2021Article
- Cardiac and renal function interactions in heart failure with reduced ejection fraction: A mathematical modeling analysis.PLoS computational biology · 2020Article
- Sensing of tubular flow and renal electrolyte transport.Nature reviews. Nephrology · 2020Review
- Preeminent role of the cardiorenal axis in the antihypertensive response to an arteriovenous fistula: an in silico analysis.American journal of physiology. Heart and circulatory physiology · 2019Article
- Myocardin ablation in a cardiac-renal rat model.Scientific reports · 2019Article
- Testing Computer Models Predicting Human Responses to a High-Salt Diet.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Role of the heart in blood pressure lowering during chronic baroreflex activation: insight from an in silico analysis.American journal of physiology. Heart and circulatory physiology · 2018Article
- Simulating a virtual population's sensitivity to salt and uninephrectomy.Interface focus · 2018Article
- Physiologic Mechanisms of Water and Electrolyte Disturbances After Transsphenoidal Pituitary Surgery.World neurosurgery · 2017Article
- An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure.Journal of the American Heart Association · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mathematical modeling is an important tool for understanding quantitative relationships among components of complex physiological systems and for testing competing hypotheses. We used HumMod, a large physiological model, to test hypotheses of blood pressure (BP) salt sensitivity. Systemic hemodynamics, renal, and neurohormonal responses to chronic changes in salt intake were examined during normal renal function, fixed low or high plasma angiotensin II (ANG II) levels, bilateral renal artery stenosis, increased renal sympathetic nerve activity (RSNA), and decreased nephron numbers. Simulations were run for 4 wk at salt intakes ranging from 30 to 1,000 mmol/day. Reducing functional kidney mass or fixing ANG II increased salt sensitivity. Salt sensitivity, associated with inability of ANG II to respond to changes in salt intake, occurred with smaller changes in renal blood flow but greater changes in glomerular filtration rate, renal sodium reabsorption, and total peripheral resistance (TPR). However, clamping TPR at normal or high levels had no major effect on salt sensitivity. There were no clear relationships between BP salt sensitivity and renal vascular resistance or extracellular fluid volume. Our robust mathematical model of cardiovascular, renal, endocrine, and sympathetic nervous system physiology supports the hypothesis that specific types of kidney dysfunction, associated with impaired regulation of ANG II or increased tubular sodium reabsorption, contribute to BP salt sensitivity. However, increased preglomerular resistance, increased RSNA, or inability to decrease TPR does not appear to influence salt sensitivity. This model provides a platform for testing competing concepts of long-term BP control during changes in salt intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.