ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
- Central Bradypnea and Ataxic Breathing in Myotonic Dystrophy Type 1 - A Clinical Case Report.Journal of neuromuscular diseases · 2023Article
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- Mechanisms of opioid-induced respiratory depression.Archives of toxicology · 2022Review
- Automated evaluation of respiratory signals to provide insight into respiratory drive.Respiratory physiology & neurobiology · 2022Article
- Breathing rate variability in obstructive sleep apnea during wakefulness.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Interaction between the pulmonary stretch receptor and pontine control of expiratory duration.Respiratory physiology & neurobiology · 2021Article
- Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.Archives of toxicology · 2021Review
- Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.Journal of neurophysiology · 2021Review
- Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia.Scientific reports · 2021Article
- Multi-Level Regulation of Opioid-Induced Respiratory Depression.Physiology (Bethesda, Md.) · 2020Review
- Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.Respiratory physiology & neurobiology · 2020Article
- Respiratory regulation & interactions with neuro-cognitive circuitry.Neuroscience and biobehavioral reviews · 2020Review
- Differential impact of two critical respiratory centres in opioid-induced respiratory depression in awake mice.The Journal of physiology · 2020Article
- Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency.Respiratory physiology & neurobiology · 2019Article
- Ventilatory pattern variability as a biometric for severity of acute lung injury in rats.Respiratory physiology & neurobiology · 2019Article
- Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation.Frontiers in physiology · 2019Article
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- REM sleep respiratory behaviours mental content in narcoleptic lucid dreamers.Scientific reports · 2018Article
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4 authors.
Funding
Abstract
Respiration varies from breath to breath. On the millisecond timescale of spiking, neuronal circuits exhibit variability due to the stochastic properties of ion channels and synapses. Does this fast, microscopic source of variability contribute to the slower, macroscopic variability of the respiratory period? To address this question, we modeled a stochastic oscillator with forcing; then, we tested its predictions experimentally for the respiratory rhythm generated by the in situ perfused preparation during vagal nerve stimulation (VNS). Our simulations identified a relationship among the gain of the input, entrainment strength, and rhythm variability. Specifically, at high gain, the periodic input entrained the oscillator and reduced variability, whereas at low gain, the noise interacted with the input, causing events known as "phase slips", which increased variability on a slow timescale. Experimentally, the in situ preparation behaved like the low-gain model: VNS entrained respiration but exhibited phase slips that increased rhythm variability. Next, we used bilateral muscimol microinjections in discrete respiratory compartments to identify areas involved in VNS gain control. Suppression of activity in the nucleus tractus solitarii occluded both entrainment and amplification of rhythm variability by VNS, confirming that these effects were due to the activation of the Hering-Breuer reflex. Suppressing activity of the Kölliker-Fuse nuclei (KFn) enhanced entrainment and reduced rhythm variability during VNS, consistent with the predictions of the high-gain model. Together, the model and experiments suggest that the KFn regulates respiratory rhythm variability via a gain control mechanism.
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