Evidence map›Paper›PMID 27974312›Full record

ArticleThe American journal of clinical nutrition2017

Dietary patterns and cardiometabolic and endocrine plasma biomarkers in US women.

Hala B AlEssa, Vasanti S Malik, Changzheng Yuan, Walter C Willett, Tianyi Huang, Frank B Hu, Deirdre K Tobias

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  17. Association of Inflammatory and Insulinemic Potential of Diet and Lifestyle with Risk of Hepatocellular Carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hala B AlEssaDepartments of Nutrition and.ORCID 0000-0002-6871-3379
Vasanti S MalikDepartments of Nutrition and.
Changzheng YuanDepartments of Nutrition and.
Walter C WillettDepartments of Nutrition and.
Tianyi HuangEpidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; and.
Frank B HuDepartments of Nutrition and.
Deirdre K TobiasDepartments of Nutrition and dtobias@partners.org.
Brigham and Women's Hospital · USHarvard University · US

Funding

Metabolomics and type 2 diabetes risk among high-risk women with a history of gestational diabetesK01DK103720 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI TOBIAS, DEIRDRE KAY · 2014 to 2016
$396k
NICHD NIH HHS L30 HD074066NIDDK NIH HHS K01 DK103720
6 · The paper itself

Abstract

backgroundHealthful dietary patterns have been associated with lower risks of type 2 diabetes and coronary artery disease, but their relations with intermediate markers of cardiometabolic and endocrine health are less established.

objectiveWe evaluated the Dietary Approaches to Stop Hypertension (DASH), the alternate Mediterranean diet (aMED), and the Alternate Healthy Eating Index (aHEI) diet-quality scores with cardiometabolic and endocrine plasma biomarkers in US women.

designThe trial was a cross-sectional analysis of 775 healthy women in the Women's Lifestyle Validation Study that was conducted within the NHS (Nurses' Health Study) and NHS II longitudinal cohorts. Multiple linear regression models adjusted for potential confounders were used to estimate associations between quartiles of dietary pattern-adherence scores that were derived from a food-frequency questionnaire and plasma biomarker concentrations that were collected simultaneously.

resultsIn multivariable models in which highest and lowest quartiles of dietary pattern scores were compared, 1) DASH was significantly associated with higher concentrations of high-density lipoprotein (9%) and sex-hormone binding globulin (SHBG) (21%), and lower concentrations of leptin (28%), triglycerides (19%), and C-peptide (4%) (all P-trend ≤ 0.04); 2) the aMED was associated with 19% higher SHBG and 16% lower triglycerides (P-trend = 0.02 and 0.003, respectively); and 3) the aHEI was associated with significantly higher concentrations of insulin (16%) and SHBG (19%) and lower concentrations of leptin (18%) (all P-trend ≤ 0.02). Further adjustment for body mass index (BMI) attenuated these associations but remained significant for 1) DASH with leptin and triglycerides and 2) the aMED with triglycerides (all P-trend ≤ 0.03).

conclusionsAdherence to healthful dietary patterns is associated with favorable concentrations of many cardiometabolic and endocrine biomarkers. These relations are mediated in part by BMI.

Indexed as

Diet, MediterraneanAdiponectinAgedBiomarkersBody Mass IndexCardiovascular DiseasesCholesterol, HDLC-PeptideCross-Sectional StudiesFemaleFolic AcidFollow-Up StudiesHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILeptinAdiponectinBiomarkersCholesterol, HDLC-PeptideFolic AcidIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILEPR protein, humanLeptinReceptors, LeptinSex Hormone-Binding GlobulinTriglyceridesaHEIalternate Mediterranean dietcardiometabolic biomarkersDASHdietary patterns

Identifiers

PMID27974312
PMCPMC5267305
OpenAlexW2562480087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.