ArticleAnnals of the rheumatic diseases2017
Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.
Article in Annals of the rheumatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Single-Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation.Journal of cardiovascular electrophysiology · 2026Article
- Use of dual-energy X-ray absorptiometry to evaluate variation in bone shape and alignment associated with radiographic knee osteoarthritis: Findings from a study of 19,053 individuals in UK Biobank.Osteoarthritis and cartilage open · 2025Article
- Endophenotypes of Primary Osteoarthritis of the Hip Joint in the Bulgarian Population over 60 Years Old.Life (Basel, Switzerland) · 2024Article
- The Kinesin GeneInternational journal of molecular sciences · 2022Article
- Genetics of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
- LRCH1 deficiency enhances LAT signalosome formation and CD8Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identifying novel associations in GWAS by hierarchical Bayesian latent variable detection of differentially misclassified phenotypes.BMC bioinformatics · 2020Article
- LRCH1 suppresses migration of CD4International journal of medical sciences · 2020Article
- Structure and Emerging Functions of LRCH Proteins in Leukocyte Biology.Frontiers in cell and developmental biology · 2020Review
- Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Functional testing of thousands of osteoarthritis-associated variants for regulatory activity.Nature communications · 2019Article
- Annotating Transcriptional Effects of Genetic Variants in Disease-Relevant Tissue: Transcriptome-Wide Allelic Imbalance in Osteoarthritic Cartilage.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Some patients (and some of us) respond better to some biological therapies: the as yet unsolved conundrum.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2018Article
- Epidemiology of osteoarthritis: literature update.Current opinion in rheumatology · 2018Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveOsteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of clinically relevant endophenotyping according to site of maximal joint space narrowing (maxJSN) and bone remodelling response on GWAS signal detection in hip OA.
methodsA stratified GWAS meta-analysis was conducted in 2118 radiographically defined hip OA cases and 6500 population-based controls. Signals were followed up by analysing differential expression of proximal genes for bone remodelling endophenotypes in 33 pairs of macroscopically intact and OA-affected cartilage.
resultsWe report suggestive evidence (p<5×10
conclusionsOur findings demonstrate that stratification of OA cases into more homogeneous endophenotypes can identify genes of potential functional importance otherwise obscured by disease heterogeneity.
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