Evidence map›Paper›PMID 27974223›Full record

ArticleStem cell reports2016

Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis.

Nicole Dominado, John E La Marca, Nicole A Siddall, James Heaney, Mai Tran, Yu Cai, Fengwei Yu, Hongyan Wang, W Gregory Somers, Leonie M Quinn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. A tumor suppressor Retinoblastoma1 is essential for embryonic development in the sea urchin.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicole DominadoCentre for Stem Cell Systems, Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia.
John E La MarcaDepartment of Genetics, La Trobe University, Melbourne, VIC 3086, Australia.
Nicole A SiddallCentre for Stem Cell Systems, Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia.
James HeaneyCentre for Stem Cell Systems, Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia.
Mai TranDepartment of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia.
Yu CaiTemasek Life Sciences Laboratory, National University of Singapore, Singapore 117543, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore.
Fengwei YuTemasek Life Sciences Laboratory, National University of Singapore, Singapore 117543, Singapore.
Hongyan WangNeuroscience & Behavioral Disorder Program, Duke-National University of Singapore, Singapore 169857, Singapore; Department of Physiology, National University of Singapore, Singapore 117597, Singapore.
W Gregory SomersDepartment of Genetics, La Trobe University, Melbourne, VIC 3086, Australia.
Leonie M QuinnDepartment of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia; The John Curtin School of Medical Research, The Australian National University, Acton, ACT 2601, Australia. Electronic address: l.quinn@unimelb.edu.au.
Gary R HimeCentre for Stem Cell Systems, Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia. Electronic address: g.hime@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or niche, to control organ growth in vivo. Here, we report the identification of two independent alleles for the highly conserved tumor suppressor gene, Retinoblastoma-family protein (Rbf), in a screen for testis phenotypes in X chromosome third-instar lethal alleles. Rbf mutant alleles exhibit overproliferation of spermatogonial cells, which is phenocopied by the molecularly characterized Rbf

Indexed as

Cell LineageSpermatogenesisAnimalsCell DifferentiationCell ProliferationDrosophila melanogasterDrosophila ProteinsGerm CellsLarvaMaleMutationRetinoblastoma ProteinStem Cell NicheStem CellsTestisTranscription FactorsDrosophila ProteinsRbf protein, DrosophilaRetinoblastoma ProteinTranscription FactorsDrosophilagermlineproliferationretinoblastoma proteinself-renewalstem cellstem cell nichetestis

Identifiers

PMID27974223
PMCPMC5161748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.