Evidence map›Paper›PMID 27974211›Full record

ArticleCell reports2016

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.

Xiaolin Luo, Rui Liao, Kaisa L Hanley, Helen He Zhu, Kirsten N Malo, Carolyn Hernandez, Xufu Wei, Nissi M Varki, Nazilla Alderson, Catherine Chu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 60 citations in OpenAlex.

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  20. Oncology letters · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Xiaolin LuoDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Rui LiaoDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Department of Hepatobiliary Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 40016, China.
Kaisa L HanleyMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Helen He ZhuDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Kirsten N MaloMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Carolyn HernandezDepartment of Medicine, NAFLD Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
Xufu WeiDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Hepatobiliary Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 40016, China.
Nissi M VarkiDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Nazilla AldersonDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Catherine ChuMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Shuangwei LiDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Jia FanLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Rohit LoombaDepartment of Medicine, NAFLD Research Center, University of California, San Diego, La Jolla, CA 92093, USA.
Shuang-Jian QiuLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Gen-Sheng FengDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: gfeng@ucsd.edu.
University of California, San Diego · USFirst Affiliated Hospital of Chongqing Medical University · CNFudan University · CNSun Yat-sen University · CNZhongshan Hospital · CN

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Dissection of Pten-regulated signals in hepatopathogenesisR01CA188506 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENG, GEN-SHENG · 2015 to 2019
$1.9M
Molecular and Cellular Communications in Liver TumorigenesisR01CA176012 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENG, GEN-SHENG · 2014 to 2019
$1.7M
NCI NIH HHS R01 CA176012NCI NIH HHS R01 CA188506NIGMS NIH HHS T32 GM007240
6 · The paper itself

Abstract

The complexity of liver tumorigenesis is underscored by the recently observed anti-oncogenic effects of oncoproteins, although the mechanisms are unclear. Shp2/Ptpn11 is a proto-oncogene in hematopoietic cells and antagonizes the effect of tumor suppressor Pten in leukemogenesis. In contrast, we show here cooperative functions of Shp2 and Pten in suppressing hepatocarcinogenesis. Ablating both Shp2 and Pten in hepatocytes induced early-onset non-alcoholic steatohepatitis (NASH) and promoted genesis of liver tumor-initiating cells likely due to augmented cJun expression/activation and elevated ROS and inflammation in the hepatic microenvironment. Inhibiting cJun partially suppressed NASH-driven liver tumorigenesis without improving NASH. SHP2 and PTEN deficiencies were detected in liver cancer patients with poor prognosis. These data depict a mechanism of hepato-oncogenesis and suggest a potential therapeutic strategy.

Indexed as

AnimalsCarcinogenesisCarcinoma, HepatocellularDisease Models, AnimalGene Expression Regulation, NeoplasticHumansJNK Mitogen-Activated Protein KinasesLiverLiver NeoplasmsMice, KnockoutNeoplastic Stem CellsNon-alcoholic Fatty Liver DiseaseProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene MasPTEN PhosphohydrolaseSignal TransductionJNK Mitogen-Activated Protein KinasesMAS1 protein, humanProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene MasPTEN PhosphohydrolasePTEN protein, humanPtpn11 protein, mouseliver tumorigenesisnon-alcoholic steatohepatitisPTENShp2tumor-initiating cellstumor suppressor

Identifiers

PMID27974211
PMCPMC5330282
OpenAlexW2566268981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.