Evidence map›Paper›PMID 27974195›Full record

ArticleCell reports2016

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux.

Raya Ahmed, Laureline Roger, Pedro Costa Del Amo, Kelly L Miners, Rhiannon E Jones, Lies Boelen, Tinhinane Fali, Marjet Elemans, Yan Zhang, Victor Appay and 5 more

Abstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. HEB Restrains Effector Gene Expression during Early CD8Molecular and cellular biology · 2025
    Article
  12. Deuterated water (Frontiers in immunology · 2025
    Article
  13. Review
  14. Durable CD4Trends in immunology · 2024
    Review
  15. Article
  16. Memory stem CD8Frontiers in cellular and infection microbiology · 2024
    Review
  17. Role of stem cell-like memory T cells in autoimmune diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  18. Review
  19. KIR-HLA interactions extend human CD8+ T cell lifespan in vivo.The Journal of clinical investigation · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Raya AhmedInstitute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
Laureline RogerDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Pedro Costa Del AmoDepartment of Medicine, St. Mary's Hospital, Imperial College London, London W2 1PG, UK.
Kelly L MinersDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Rhiannon E JonesDivision of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Lies BoelenDepartment of Medicine, St. Mary's Hospital, Imperial College London, London W2 1PG, UK.
Tinhinane FaliSorbonne Universités, UPMC Université Paris 06, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 75013 Paris, France; INSERM U1135, CIMI-Paris, 75013 Paris, France.
Marjet ElemansDepartment of Medicine, St. Mary's Hospital, Imperial College London, London W2 1PG, UK.
Yan ZhangInstitute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
Victor AppaySorbonne Universités, UPMC Université Paris 06, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 75013 Paris, France; INSERM U1135, CIMI-Paris, 75013 Paris, France.
Duncan M BairdDivision of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Becca AsquithDepartment of Medicine, St. Mary's Hospital, Imperial College London, London W2 1PG, UK.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: priced6@cardiff.ac.uk.
Derek C MacallanInstitute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK; St. George's University Hospitals National Health Service Foundation Trust, Blackshaw Road, London SW17 0QT, UK. Electronic address: macallan@sgul.ac.uk.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK. Electronic address: ladellk@gmail.com.

Funding

Cancer Research UK 18246Cancer Research UK C17199/A18246Medical Research Council G1001052Medical Research Council MR/J007439/1Wellcome Trust 093053/Z/10/Z
6 · The paper itself

Abstract

Adaptive immunity requires the generation of memory T cells from naive precursors selected in the thymus. The key intermediaries in this process are stem cell-like memory T (T

Indexed as

Adaptive ImmunityImmunologic MemoryCell LineageCell ProliferationCell Self RenewalHumansIsotope LabelingKi-67 AntigenStem CellsTelomeraseT-LymphocytesKi-67 AntigenTelomeraseadaptive immunityCD4(+) T cellsCD8(+) T cellsin vivo heavy water labelingmemory T cell maintenancememory T cellsproliferationstem cell-like memory T cellstelomerase activitytelomere length

Identifiers

PMID27974195
PMCPMC5186732

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.