Evidence map›Paper›PMID 27973819›Full record

ArticleThe journal of physical chemistry. B2016

Entire-Dataset Analysis of NMR Fast-Exchange Titration Spectra: A Mg

Ichhuk Karki, Martin T Christen, Justin Spiriti, Ryan L Slack, Masayuki Oda, Kenji Kanaori, Daniel M Zuckerman, Rieko Ishima

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. NMR Lineshape Analysis of Intrinsically Disordered Protein Interactions.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
  3. Article
  4. Binding thermodynamics of metal ions to HIV-1 ribonuclease H domain.Journal of thermal analysis and calorimetry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Ichhuk KarkiDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Martin T ChristenDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Justin SpiritiDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Ryan L SlackDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Masayuki OdaDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Kenji KanaoriDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Daniel M ZuckermanDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.
Rieko IshimaDepartment of Structural Biology and ‡Department of Computational and Systems Biology, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0002-3418-0922
Kyoto Prefectural University · JP

Funding

Novel antivirals targeting the RNase H activity of HIV reverse transcriptaseR01AI100890 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI SARAFIANOS, STEFAN G, WANG, ZHENGQIANG · 2012 to 2016
$3.6M
Conformational Dynamics and inhibitor responses of HIV-1 RT RNase H in solutionR01GM105401 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ISHIMA, RIEKO · 2013 to 2016
$1.4M
NIAID NIH HHS R01 AI100890NIGMS NIH HHS R01 GM105401
6 · The paper itself

Abstract

This article communicates our study to elucidate the molecular determinants of weak Mg

Indexed as

Binding SitesCatalytic DomainCations, DivalentCloning, MolecularEscherichia coliGene ExpressionGenetic VectorsHIV-1HIV Reverse TranscriptaseKineticsMagnesiumModels, MolecularMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein BindingProtein Conformation, alpha-HelicalCations, DivalentHIV Reverse TranscriptaseMagnesiumRecombinant Proteinsreverse transcriptase, Human immunodeficiency virus 1Ribonuclease H

Identifiers

PMID27973819
PMCPMC5850897
OpenAlexW2559970489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.