ArticleAntioxidants (Basel, Switzerland)2016
Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells.
Article in Antioxidants (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- Persian Medicinal Plants as Antidiabetic Agents: Mechanisms and Evidence from Bench to Bedside .Iranian biomedical journal · 2025Review
- Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy.SN comprehensive clinical medicine · 2021Article
- Antidiabetic compounds 8a, 8b, 8k, and 9h enhance insulin secretion: activity and mechanism.Endocrine · 2021Article
- The Emerging Role of Polyphenols in the Management of Type 2 Diabetes.Molecules (Basel, Switzerland) · 2021Review
- Modulation of Skin Inflammatory Response by Active Components of Silymarin.Molecules (Basel, Switzerland) · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Silymarin (SIL) is a flavonoid extracted from milk thistle seed that has been reported to decrease hyperglycemia in people with type 2 diabetes (T2D). However, it is not known whether SIL has direct secretory effects on β-cells. Using the β-cell line HIT-T15, SIL was shown to decrease intracellular peroxide levels and to augment glucose-stimulated insulin secretion (GSIS). However, the latter was observed using a concentration range of 25-100 µM, which was too low to affect endogenous peroxide levels. The stimulatory effect of SIL dissipated at higher concentrations (100-200 µM), and mild apoptosis was observed. The smaller concentrations of SIL also decreased cAMP phosphodiesterase activity in a Ca
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