ArticleMolecular and cellular biology1989
Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 92 citations in OpenAlex.
- Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms.Genome research · 2020Article
- HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The pause-initiation limit restricts transcription activation in human cells.Nature communications · 2019Article
- Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly?Frontiers in pharmacology · 2012Article
- Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.Genes & development · 2006Article
- Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine.Infection and immunity · 2002Article
- Disruption of heat shock factor 1 reveals an essential role in the ubiquitin proteolytic pathway.Molecular and cellular biology · 2000Article
- Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element.Genes & development · 1999Article
- Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.Molecular and cellular biology · 1998Article
- Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF.The EMBO journal · 1997Article
- HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator.Molecular and cellular biology · 1997Article
- The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation.Journal of virology · 1996Article
- Stress-induced transcriptional activation.Microbiological reviews · 1995Review
- The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive.Molecular and cellular biology · 1995Article
- Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.Molecular and cellular biology · 1994Article
- Elevation of heat shock protein synthesis and hsp gene transcription during monocyte to macrophage differentiation of U937 cells.Clinical and experimental immunology · 1993Article
- Dual control of heat shock response: involvement of a constitutive heat shock element-binding factor.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells.The Biochemical journal · 1993Article
- Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.Molecular and cellular biology · 1993Article
- Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.Molecular and cellular biology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hemin-induced differentiation of the human erythroleukemia cell line K562 results in the expression and accumulation of erythroid-specific gene products such as embryonic and fetal hemoglobins and the elevated synthesis of the major heat shock protein HSP70. This activity was suggested to represent activation of a heat shock gene during erythroid maturation independent of stress induction. In this study, we demonstrate that hemin induces the transcription of two members of the human HSP70 gene family, HSP70 and GRP78 (BiP). However, the induction of HSP70 by hemin showed characteristics consistent with the molecular events associated with a heat shock or stress response. The increase in HSP70 gene transcription was accompanied by induction of the stress-induced form of the heat shock transcription factor. Moreover, a heat shock element was required for the hemin responsiveness of chimeric heat shock promoter-chloramphenicol acetyltransferase genes transiently expressed in transfected K562 cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.