Evidence map›Paper›PMID 27968956›Full record

ArticleAmerican journal of otolaryngology

A genetic marker of the ACKR1 gene is present in patients with Type II congenital smell loss who have type I hyposmia and hypogeusia.

William A Stateman, Alexandra B Knöppel, Willy A Flegel, Robert I Henkin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of otolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

William A StatemanCenter for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, #20, Washington, DC, United States. Electronic address: wstateman@gmail.com.
Alexandra B KnöppelCenter for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, #20, Washington, DC, United States. Electronic address: abknoppel@gmail.com.
Willy A FlegelNIH Clinical Center, Department of Transfusion Medicine, 10 Center Drive-MSC 1184, Building 10, Room 1C711, Bethesda, MD, United States. Electronic address: flegelwa@cc.nih.gov.
Robert I HenkinCenter for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, #20, Washington, DC, United States. Electronic address: doc@tasteandsmell.com.
Taste and Smell Clinic · USNational Institutes of Health Clinical Center · US

Funding

Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

purposeOur previous study of Type II congenital smell loss patients revealed a statistically significant lower prevalence of an FY (ACKR1, formerly DARC) haplotype compared to controls. The present study correlates this genetic feature with subgroups of patients defined by specific smell and taste functions.

methodsSmell and taste function measurements were performed by use of olfactometry and gustometry to define degree of abnormality of smell and taste function. Smell loss was classified as anosmia or hyposmia (types I, II or III). Taste loss was similarly classified as ageusia or hypogeusia (types I, II or III). Based upon these results patient erythrocyte antigen expression frequencies were categorized by smell and taste loss with results compared between patients within the Type II group and published controls.

resultsComparison of antigen expression frequencies revealed a statistically significant decrease in incidence of an Fy

conclusionsData suggest that Type II congenital smell loss patients who exhibit both type I hyposmia and hypogeusia are genetically distinct from all other patients with Type II congenital smell loss. This distinction is based on decreased Fy

Indexed as

AdolescentAdultAgedCase-Control StudiesChildCohort StudiesDuffy Blood-Group SystemFemaleGenetic MarkersHumansMaleMiddle AgedOlfaction DisordersReceptors, Cell SurfaceTaste DisordersYoung AdultACKR1 protein, humanDuffy Blood-Group SystemGenetic MarkersReceptors, Cell Surface

Identifiers

PMID27968956
PMCPMC5159426
OpenAlexW913695589

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.