Evidence map›Paper›PMID 27966833›Full record

ArticleZoonoses and public health2017

Stable Transmission of Borrelia burgdorferi Sensu Stricto on the Outer Banks of North Carolina.

J F Levine, C S Apperson, M Levin, T R Kelly, M L Kakumanu, L Ponnusamy, H Sutton, S A Salger, J M Caldwell, A J Szempruch

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PubMed Full text at PMC Publisher
In one paragraph

Article in Zoonoses and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

J F LevineDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
C S AppersonDepartment of Entomology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC, USA.
M LevinNational Center for Emerging and Zoonotic Infectious Diseases, The Centers for Disease Control and Prevention, Atlanta, GA, USA.
T R KellyDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
M L KakumanuDepartment of Entomology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC, USA.
L PonnusamyDepartment of Entomology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC, USA.
H SuttonDepartment of Entomology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC, USA.
S A SalgerDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
J M CaldwellDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
A J SzempruchDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
North Carolina State University · USThe Centers · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

The spirochaete (Borrelia burgdorferi) associated with Lyme disease was detected in questing ticks and rodents during a period of 18 years, 1991-2009, at five locations on the Outer Banks of North Carolina. The black-legged tick (Ixodes scapularis) was collected at varied intervals between 1991 and 2009 and examined for B. burgdorferi. The white-footed mouse (Peromyscus leucopus), house mouse (Mus musculus) marsh rice rat (Oryzomys palustris), marsh rabbit (Sylvilagus palustris), eastern cottontail (Sylvilagus floridanus) and six-lined racerunner (Cnemidophorus sexlineatus) were live-trapped, and their tissues cultured to isolate spirochaetes. Borrelia burgdorferi isolates were obtained from questing adult I. scapularis and engorged I. scapularis removed from P. leucopus, O. palustris and S. floridanus. The prevalence of B. burgdorferi infection was variable at different times and sites ranging from 7 to 14% of examined questing I. scapularis. Mitochondrial (16S) rRNA gene phylogenetic analysis from 65 adult I. scapularis identified 12 haplotypes in two major clades. Nine haplotypes were associated with northern/Midwestern I. scapularis populations and three with southern I. scapularis populations. Sixteen isolates obtained from tick hosts in 2005 were confirmed to be B. burgdorferi by amplifying and sequencing of 16S rRNA and 5S-23S intergenic spacer fragments. The sequences had 98-99% identity to B. burgdorferi sensu stricto strains B31, JD1 and M11p. Taken together, these studies indicate that B. burgdorferi sensu stricto is endemic in questing I. scapularis and mammalian tick hosts on the Outer Banks of North Carolina.

Indexed as

AnimalsBacteriological TechniquesBorrelia burgdorferiDNA, BacterialFemaleIxodesLyme DiseaseMaleNorth CarolinaPhylogenyRabbitsReptilesRodentiaDNA, BacterialBorrelia burgdorferiIxodes scapularisNorth CarolinaOryzomys palustrisOuter BanksPeromyscus leucopusSylvilagus palustris

Identifiers

PMID27966833
PMCPMC5657000
OpenAlexW2565727817

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.