ArticleScientific reports2016
Modeling quorum sensing trade-offs between bacterial cell density and system extension from open boundaries.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- From single cells to communities: Mathematical perspectives on bacterial quorum sensing.Computational and structural biotechnology journal · 2025Review
- Probing patterning in microbial consortia with a cellular automaton for spatial organisation.Scientific reports · 2022Article
- Chaos in synthetic microbial communities.PLoS computational biology · 2022Article
- Quorum-sensing induced transitions between bistable steady-states for a cell-bulk ODE-PDE model with lux intracellular kinetics.Journal of mathematical biology · 2021Article
- Automated design of synthetic microbial communities.Nature communications · 2021Article
- Analysis of the Interaction betweenPlants (Basel, Switzerland) · 2020Article
- Burst statistics in an early biofilm quorum sensing model: the role of spatial colony-growth heterogeneity.Scientific reports · 2019Article
- The Use of Diffusion Calculations and Monte Carlo Simulations to Understand the Behavior of Cells inComputational and structural biotechnology journal · 2019Review
- Bacterial bioluminescence onset and quenching: a dynamical model for aRoyal Society open science · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial communities undergo collective behavioural switches upon producing and sensing diffusible signal molecules; a mechanism referred to as Quorum Sensing (QS). Exemplarily, biofilm organic matrices are built concertedly by bacteria in several environments. QS scope in bacterial ecology has been debated for over 20 years. Different perspectives counterpose the role of density reporter for populations to that of local environment diffusivity probe for individual cells. Here we devise a model system where tubes of different heights contain matrix-embedded producers and sensors. These tubes allow non-limiting signal diffusion from one open end, thereby showing that population spatial extension away from an open boundary can be a main critical factor in QS. Experimental data, successfully recapitulated by a comprehensive mathematical model, demonstrate how tube height can overtake the role of producer density in triggering sensor activation. The biotic degradation of the signal is found to play a major role and to be species-specific and entirely feedback-independent.
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Registered trials
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