ArticleScientific reports2016
Symbiont-derived sphingolipids modulate mucosal homeostasis and B cells in teleost fish.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Host genotype and environmental factors differentially shape the black piranha's gill microbiota.Microbiology spectrum · 2026Article
- Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens.Nature communications · 2025Article
- Unveiling the Characteristics of Microbiota in Different Mucosal Layers of Leopard Coral Grouper (Plectropomus leopardus).Marine biotechnology (New York, N.Y.) · 2025Article
- The interactions between the host immunity and intestinal microorganisms in fish.Applied microbiology and biotechnology · 2024Review
- Link between bacterial communities and contrasted loads in ectoparasitic monogeneans from the external mucus of two wild sparid species (Teleostei).Animal microbiome · 2024Article
- Debaryomyces hansenii supplementation in low fish meal diets promotes growth, modulates microbiota and enhances intestinal condition in juvenile marine fish.Journal of animal science and biotechnology · 2023Article
- Gut Microbial Composition of Pacific Salmonids Differs across Oregon River Basins and Hatchery Ancestry.Microorganisms · 2022Article
- Genetic and lipidomic analyses suggest thatAccess microbiology · 2022Article
- Gill and Liver Transcript Expression Changes Associated With Gill Damage in Atlantic Salmon (Frontiers in immunology · 2022Article
- Mucosal immunoglobulins of teleost fish: A decade of advances.Developmental and comparative immunology · 2021Review
- The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons.The Science of the total environment · 2021Article
- Insights into the Natural Defenses of a Coral Reef Fish Against Gill Ectoparasites: Integrated Metabolome and Microbiome Approach.Metabolites · 2020Article
- Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish.Frontiers in immunology · 2020Review
- Engineering the microbiome for animal health and conservation.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Sex, Age, and Bacteria: How the Intestinal Microbiota Is Modulated in a Protandrous Hermaphrodite Fish.Frontiers in microbiology · 2019Article
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Symbiont-derived sphingolipids regulate inflammatory responses in rainbow trout (Aquaculture (Amsterdam, Netherlands) · 2018Article
- CK12a, a CCL19-like Chemokine That Orchestrates both Nasal and Systemic Antiviral Immune Responses in Rainbow Trout.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Under Pressure: Interactions between Commensal Microbiota and the Teleost Immune System.Frontiers in immunology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Symbiotic bacteria and mucosal immunoglobulins have co-evolved for millions of years in vertebrate animals. Symbiotic bacteria products are known to modulate different aspects of the host immune system. We recently reported that Flectobacillus major is a predominant species that lives in the gill and skin mucosal surfaces of rainbow trout (Oncorhynchus mykiss). F. major is known to produce sphingolipids of a unique molecular structure. Here we propose a role for F. major and its sphingolipids in the regulation of B cell populations in rainbow trout, as well as an essential role for sphingolipids in trout mucosal homeostasis. We found that F. major-specific IgT titers are confined to the gill and skin mucus, whereas F. major-specific IgM titers are only detected in serum. Live F. major cells are able to stimulate sustained IgT expression and secretion in gills. F. major sphingolipids modulate the growth of trout total skin and gill symbiotic bacteria. In vivo systemic administration of F. major sphingolipids changes the proportion of IgT
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.