ArticleScientific reports2016
Gene network analysis identifies rumen epithelial cell proliferation, differentiation and metabolic pathways perturbed by diet and correlated with methane production.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Reliable enteric methane prediction from the cattle (Bos taurus) rumen microbiome.Communications biology · 2026Article
- Transcriptomic characterization of the functional and morphological development of the rumen wall in weaned lambs fed a diet containing yeast co-cultures ofFrontiers in veterinary science · 2025Article
- Connecting the ruminant microbiome to climate change: insights from current ecological and evolutionary concepts.Frontiers in microbiology · 2024Review
- Microbiota-host crosstalk in the newborn and adult rumen at single-cell resolution.BMC biology · 2022Article
- The rumen microbiome: balancing food security and environmental impacts.Nature reviews. Microbiology · 2021Review
- Genetic parameters of plasma and ruminal volatile fatty acids in sheep fed alfalfa pellets and genetic correlations with enteric methane emissions1.Journal of animal science · 2019Article
- Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle.Microbiome · 2019Article
- Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression.G3 (Bethesda, Md.) · 2019Article
- A Gene Expression Atlas of the Domestic Water Buffalo (Frontiers in genetics · 2019Article
- Protein profiles of enzymatically isolated rumen epithelium in sheep fed a fibrous diet.Journal of animal science and biotechnology · 2019Article
- A Mini-Atlas of Gene Expression for the Domestic Goat (Frontiers in genetics · 2019Article
- Across-Experiment Transcriptomics of Sheep Rumen Identifies Expression of Lipid/Oxo-Acid Metabolism and Muscle Cell Junction Genes Associated With Variation in Methane-Related Phenotypes.Frontiers in genetics · 2018Article
- A high resolution atlas of gene expression in the domestic sheep (Ovis aries).PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ruminants obtain nutrients from microbial fermentation of plant material, primarily in their rumen, a multilayered forestomach. How the different layers of the rumen wall respond to diet and influence microbial fermentation, and how these process are regulated, is not well understood. Gene expression correlation networks were constructed from full thickness rumen wall transcriptomes of 24 sheep fed two different amounts and qualities of a forage and measured for methane production. The network contained two major negatively correlated gene sub-networks predominantly representing the epithelial and muscle layers of the rumen wall. Within the epithelium sub-network gene clusters representing lipid/oxo-acid metabolism, general metabolism and proliferating and differentiating cells were identified. The expression of cell cycle and metabolic genes was positively correlated with dry matter intake, ruminal short chain fatty acid concentrations and methane production. A weak correlation between lipid/oxo-acid metabolism genes and methane yield was observed. Feed consumption level explained the majority of gene expression variation, particularly for the cell cycle genes. Many known stratified epithelium transcription factors had significantly enriched targets in the epithelial gene clusters. The expression patterns of the transcription factors and their targets in proliferating and differentiating skin is mirrored in the rumen, suggesting conservation of regulatory systems.
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