Trial reportScientific reports2016
Gait patterns associated with thyroid function: The Rotterdam Study.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Explainable AI reveals temporal risk pathways in fall prediction: Extracting clinical insights from multi-horizon machine learning models.GeroScience · 2026Article
- Article
- Association of gait speed with risk of diabetes mellitus among older adults: findings from the China health and retirement longitudinal study.BMC geriatrics · 2025Article
- A comprehensive investigation to examine the factors associated with previous falls, recurrent falls, and concerns about falling among outpatient older individuals: a cross-sectional study.European geriatric medicine · 2025Article
- Association between free T3 and sarcopenia in euthyroid older patients with Hashimoto's thyroiditis.Frontiers in endocrinology · 2025Article
- Does autoimmune diseases increase the risk of frailty? A Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Prevalence of thyroid dysfunction among Iranian older adults: a cross-sectional study.Scientific reports · 2023Article
- Age-related variation in thyroid function - a narrative review highlighting important implications for research and clinical practice.Thyroid research · 2023Review
- Aging under endocrine hormone regulation.Frontiers in endocrinology · 2023Review
- Spatio-Temporal Gait Parameters in Association with Medications and Risk of Falls in the Elderly.Clinical interventions in aging · 2022Article
- Thyroid hormones in diabetes, cancer, and aging.Aging cell · 2020Review
- The Rotterdam Study: 2018 update on objectives, design and main results.European journal of epidemiology · 2017Article
- Evidence-Based Enhancements in the Nuclear Medicine Therapy Wards: Change from the Disease/Treatment-Centric Patient Care to Holistic Care.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gait is an important health indicator and poor gait is strongly associated with disability and risk of falls. Thyroid dysfunction is suggested as a potential determinant of gait deterioration, but this has not been explored in a population-based study. We therefore investigated the association of thyroid function with gait patterns in 2645 participants from the Rotterdam Study with data available on TSH (thyroid-stimulating hormone), FT4 (free thyroxine) and gait, without known thyroid disease or dementia. The primary outcome was Global gait (standardized Z-score), while secondary outcomes included gait domains (Rhythm, Variability, Phases, Pace, Base of support, Tandem, Turning) and velocity. Gait was assessed by electronic walkway. Multivariable regression models revealed an inverted U-shaped association of TSH (p < 0.001), but no association of FT4 concentrations with Global gait (p = 0.2). TSH levels were positively associated with Base of support (p = 0.01) and followed an inverted U-shaped curve with Tandem (p = 0.002) and velocity (p = 0.02). Clinical and subclinical hypothyroidism were associated with worse Global gait than euthyroidism (β = -0.61; CI = -1.03, -0.18; p = 0.004 and β = -0.13; CI = -0.26, -0.00; p = 0.04, respectively). In euthyroid participants, higher thyroid function was associated with worse gait patterns. In conclusion, both low and high thyroid function are associated with alterations in Global gait, Tandem, Base of support and velocity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.