Trial reportScientific reports2016
Urinary KIM-1: a novel biomarker for evaluation of occupational exposure to lead.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of a 3% gelatin solution on urinary KIM-1 levels in patients after thyroidectomy: a preliminary randomized controlled trial.Scientific reports · 2021Trial
- The toxic footprint of lead exposure: oxido-inflammatory biomarkers in urban populations of Niger Delta, Nigeria.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Eucalyptol alleviates lead-induced nephrotoxicity in rats by suppressing oxidative stress, inflammation, and apoptosis, and enhancing the Nrf2/HO-1 signaling pathway.Biological trace element research · 2026Article
- Activatable fluorescent ratiometric probes for early diagnosis and prognostic assessment of acute kidney injury.Science advances · 2025Article
- Evaluation of urinary kidney injury molecule-1 in cats with chronic kidney disease.Journal of feline medicine and surgery · 2025Article
- Association between chronic lead exposure and markers of kidney injury: A systematic review and meta-analysis.Toxicology reports · 2024Article
- Article
- Associations of mixed metal exposure with chronic kidney disease from NHANES 2011-2018.Scientific reports · 2024Article
- Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) as markers of active lupus nephritis.Clinical rheumatology · 2024Article
- Early transcriptomic signatures and biomarkers of renal damage due to prolonged exposure to embedded metal.Cell biology and toxicology · 2023Article
- Evaluation of the lead removal capacity by the adsorption process ofRSC advances · 2023Article
- NLRP3 inflammasome in rosmarinic acid-afforded attenuation of acute kidney injury in mice.Scientific reports · 2022Article
- Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health.Biomarker insights · 2022Review
- Prenatal blood lead levels and reduced preadolescent glomerular filtration rate: Modification by body mass index.Environment international · 2021Article
- Effect of embedded metal fragments on urinary metal levels and kidney biomarkers in the Sprague-Dawley rat.Toxicology reports · 2021Article
- Biochemical evaluation of kidney disease.Translational andrology and urology · 2019Review
- Chronic Kidney Disease and Exposure to Nephrotoxic Metals.International journal of molecular sciences · 2017Review
- Relationship and Accuracy of Urine Lead as an Alternative to Blood Lead Biomarker among Panel Beaters in Enugu Metropolis: Nigeria.Indian journal of occupational and environmental medicineArticle
- Exploring Kidney Injury Molecule-1 and HAVCR1 Polymorphisms as Predictive Biomarkers in Chronic Kidney Disease.Kidney diseases (Basel, Switzerland)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic occult lead poisoning often develops ensuing occupational lead exposure. Early diagnosis of lead poisoning is critical for timely discontinuation of lead exposure and for prognosis. This study explored the value of urinary kidney injury molecule-1 (KIM-1) in diagnosing renal injury induced by lead at an early stage. We retrospectively analyzed 92 workers exposed to occupational lead and demonstrated a better correlation ship between blood lead levels and urine excretion of KIM-1 than other traditional renal injury biomarkers following creatinine adjustment. Receiver operating characteristic curve analysis of the ability of diverse biomarkers for predicting kidney injury in lead-exposed workers demonstrated that the order of predicting accuracy of the studied biomarkers is as follows: urinary KIM-1-to-creatinine ratio > urinary N-acetyl-β-(D)-glucosaminidase-to-creatinine ratio > urinary β2-microglobulin-to-creatinine ratio > urinary α1-microglobulin-to-creatinine ratio, with the Youden index being 16.59 ng/g, 14.01 U/g, 0.15 mg/g, and 4.63 mg/g, respectively. Collectively, our findings suggest that short-period occupational lead exposure may cause injury of renal tubules. Urinary excretion of KIM-1 correlates with blood lead levels better than other traditional renal injury biomarkers, including N-acetyl-β-(D)-glucosaminidase, α1-microglobulin, and β2-microglobulin. Longitudinal surveillance of urinary KIM-1 may aid for early diagnosis of renal tubular injury in workers with occupational lead exposure.
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