Evidence map›Paper›PMID 27966553›Full record

ArticleMucosal immunology2017

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43.

W Wu, M Sun, F Chen, A T Cao, H Liu, Y Zhao, X Huang, Y Xiao, S Yao, Q Zhao and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 296 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
296citing papers in PubMed, 6 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

296 citing papers in PubMed, 6 syntheses or guidelines pooled it, 467 citations in OpenAlex.

  1. Pooled it
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  4. Journal of microbiology and biotechnology · 2025
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  19. Bursa of Fabricius-independent B cells establish an IgA-mediated intestinal barrier that safeguards gut-liver homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Article

236 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

W WuDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
M SunDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
F ChenDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
A T CaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
H LiuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Y ZhaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
X HuangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Y XiaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
S YaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Q ZhaoBristol-Myers Squibb, Princeton, NJ, USA.
Z LiuDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Y CongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · USTongji University · CNBristol-Myers Squibb (United States) · US

Funding

Th17-IgA Axis in Regulation of Intestinal InflammationR01DK105585 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2016 to 2020
$1.8M
microRNA-10a Regulation of Inflammatory Bowel DiseasesR01DK098370 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2013 to 2016
$1.3M
NIDDK NIH HHS R01 DK098370NIDDK NIH HHS R01 DK105585
6 · The paper itself

Abstract

Intestinal IgA, which is regulated by gut microbiota, has a crucial role in maintenance of intestinal homeostasis and in protecting the intestines from inflammation. However, the means by which microbiota promotes intestinal IgA responses remain unclear. Emerging evidence suggests that the host can sense gut bacterial metabolites in addition to pathogen-associated molecular patterns and that recognition of these small molecules influences host immune response in the intestines and beyond. We reported here that microbiota metabolite short-chain fatty acid acetate promoted intestinal IgA responses, which was mediated by "metabolite-sensing" GPR43. GPR43

Indexed as

AcetatesAldehyde Dehydrogenase 1 FamilyAnimalsButyratesCells, CulturedDendritic CellsFatty Acids, VolatileFemaleImmunity, MucosalImmunoglobulin AIntestinesMiceMice, Inbred C57BLMice, KnockoutMicrobiotaReceptors, G-Protein-CoupledAcetatesAldehyde Dehydrogenase 1 FamilyALDH1A2 protein, humanButyratesFatty Acids, VolatileFfar2 protein, mouseImmunoglobulin AReceptors, G-Protein-CoupledRetinal DehydrogenaseTretinoinVitamin A

Identifiers

PMID27966553
PMCPMC5471141
OpenAlexW2560875835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.