Evidence map›Paper›PMID 27966552›Full record

ArticleMucosal immunology2017

Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7.

S Hashimoto-Hill, L Friesen, M Kim, C H Kim

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Targeting P2X Receptors-Current Progress in Sepsis.International journal of inflammation · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Tissue-resident memory CD8Nature immunology · 2022
    Article
  17. Article
  18. Article
  19. P2X7 Receptor Expression and Signaling on Dendritic Cells and CD4Frontiers in cell and developmental biology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S Hashimoto-HillLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, West Lafayette, Indiana, USA.
L FriesenLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, West Lafayette, Indiana, USA.
M KimLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, West Lafayette, Indiana, USA.
C H KimLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, West Lafayette, Indiana, USA.
Purdue University West Lafayette · USCenter for Cancer Research · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Homing of Functionally Distinct ILC SubsetsR01AI121302 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CHANG H · 2016 to 2020
$1.9M
FoxP3+ T cells of mucosal tissuesR01AI074745 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2008 to 2012
$1.7M
Therapeutic delivery of FoxP3+ T cells to the intestineR01DK076616 · NIDDK · PURDUE UNIVERSITY · PI KIM, CHANG H · 2008 to 2012
$1.5M
Migration and function of Th17 cells in the gutR01AI080769 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2010 to 2013
$1.3M
NCI NIH HHS P30 CA023168NIAID NIH HHS R01 AI074745NIAID NIH HHS R01 AI080769NIAID NIH HHS R01 AI121302NIDDK NIH HHS R01 DK076616
6 · The paper itself

Abstract

The intestinal environment harbors a large number of activated T cells, which are potentially inflammatory. To prevent inflammatory responses, intestinal T cells are controlled by various tolerogenic mechanisms, including T-cell apoptosis. We investigated the expression mechanism and function of the purinergic receptor P2X7 in contraction of intestinal CD4

Indexed as

AnimalsApoptosisCells, CulturedColitisFemaleHomeodomain ProteinsHumansIntestinesMaleMiceMice, Inbred C57BLMice, KnockoutModels, AnimalReceptors, Purinergic P2X7Th17 CellsTh1 CellsHomeodomain ProteinsP2RX7 protein, humanRAG-1 proteinReceptors, Purinergic P2X7Tretinoin

Identifiers

PMID27966552
PMCPMC5471139
OpenAlexW2566682428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.