ArticleeLife2016
Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.
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Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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Who cites it
60 citing papers in PubMed, 94 citations in OpenAlex.
- EBF1 regulates sensory establishment in the cochlea by positioning the medial boundary of the prosensory domain and restricting proliferation of the sensory progenitor population.Development (Cambridge, England) · 2026Article
- The H3K9me2-FOXG1-microRNA axis reduces cochlear hair cells damage by modulating autophagy in age-related hearing loss.Frontiers in molecular neuroscience · 2026Article
- Article
- PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse organ of Corti.Developmental biology · 2025Article
- The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration.Nature communications · 2025Article
- Modes of Notch signalling in development and disease.Nature reviews. Molecular cell biology · 2025Review
- Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea.Cells · 2025Article
- The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling.The Journal of cell biology · 2025Article
- Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2.Cell reports · 2025Article
- The Hippo pathway and p27Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rational design of a Lfng-enhancer AAV construct drives specific and efficient gene expression in inner ear supporting cells.Hearing research · 2025Article
- Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea.Development (Cambridge, England) · 2024Article
- Reprogramming withPNAS nexus · 2024Article
- A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2.Development (Cambridge, England) · 2024Article
- Deletion of the Ebf1, a mouse deafness gene, causes a dramatic increase in hair cells and support cells of the organ of Corti.Development (Cambridge, England) · 2024Article
- 3D reconstruction of the mouse cochlea from scRNA-seq data suggests morphogen-based principles in apex-to-base specification.Developmental cell · 2024Article
- Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mapping the developmental potential of mouse inner ear organoids at single-cell resolution.iScience · 2024Article
- Expression ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Martin L BaschDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Rogers M BrownProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.
Hsin-I JenProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.
Fatih SemerciProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.
Frederic DepreuxDepartment of Cell Biology and Anatomy, Rosalind Franklin University of Medicine and Science, Chicago, United States.
Renée K EdlundProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.
Hongyuan ZhangDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Christine R NortonMaine Medical Center Research Institute, Scarborough, United States.
Thomas GridleyMaine Medical Center Research Institute, Scarborough, United States.
Susan E ColeDepartment of Molecular Genetics, The Ohio State University, Columbus, United States.
Angelika DoetzlhoferSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, United States.
Mirjana Maletic-SavaticDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Neil SegilDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States.
Andrew K GrovesDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID http://orcid.org/0000-0002-0784-7998
Baylor College of Medicine · USMaine Medical Center Research Institute · USJohns Hopkins University · USRosalind Franklin University of Medicine and Science · USThe Ohio State University · USUniversity of Southern California · US
Funding
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4MEnhancing Atoh1 function in hair cell regenerationR01DC014832 · NIDCD · WASHINGTON UNIVERSITY · PI Gabriel Corfas, Andrew K Groves · 2016 to 2026
$6.7MTraining in Hearing & Communication NeuroscienceT32DC009975 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher A Shera · 2009 to 2026
$5.0MNotch Signaling Pathways in Auditory Supporting Cell Differentiation and MaintenanceR01DC011571 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DOETZLHOFER, ANGELIKA · 2011 to 2020
$3.8MGenetic Regulation of Cochlear DevelopmentR01DC006185 · NIDCD · HOUSE RESEARCH INSTITUTE · PI GROVES, ANDREW K · 2003 to 2014
$3.6MCELL CYCLE IN DEVELOPMENT / REGENERATION OF THE INNER EAR01DC004189 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SEGIL, NEIL · 1999 to 2011
$3.6MNIDCD NIH HHS R01 DC004189NIDCD NIH HHS R01 DC006185NIDCD NIH HHS R01 DC011571NIDCD NIH HHS R01 DC014832NIDCD NIH HHS T32 DC009975NIGMS NIH HHS R25 GM056929
Abstract
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers,
Indexed as
Signal TransductionAnimalsGlucosyltransferasesGlycosyltransferasesMiceMutationOrgan of CortiProteinsReceptors, NotchGlucosyltransferasesGlycosyltransferasesLfng protein, mouseMfng protein, mouseProteinsReceptors, Notchcell biologycochleadevelopmental biologyFringehair cellinner earlateral inhibitionmouseNotchstem cells
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.