ArticleThe Journal of physiology2017
Parasympathetic withdrawal increases heart rate after 2 weeks at 3454 m altitude.
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.The Journal of physiology · 2026Review
- Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity.Scientific reports · 2025Article
- Cardiac parasympathetic denervation reduces hypoxic tachycardia, baroreflex sensitivity and heart rate variability in humans.Scientific reports · 2025Article
- Analysis of changes in heart rate variability after prolonged ultra-high plateau residence in young healthy population: a cross-sectional study.Frontiers in physiology · 2025Article
- The physiological basis for individualized oxygenation targets in critically ill patients with circulatory shock.Intensive care medicine experimental · 2024Review
- Quercetin prophylaxis protects the kidneys by modulating the renin-angiotensin-aldosterone axis under acute hypobaric hypoxic stress.Scientific reports · 2024Article
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- The neuroimmune pathway of high-altitude adaptation: influence of erythrocytes on attention networks through inflammation and the autonomic nervous system.Frontiers in neuroscience · 2024Article
- A prospective, self-controlled study of sub-plateau heart rate variability in healthy adults.Frontiers in physiology · 2024Article
- Hypobaric hypoxia and cardiac baroreflex sensitivity in young women.American journal of physiology. Heart and circulatory physiology · 2022Article
- Modeling the oxygen transport to the myocardium at maximal exercise at high altitude.Physiological reports · 2022Article
- Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.Physiological reviews · 2021Review
- Ethnic Differences on Cardiac Rhythms and Autonomic Nervous System Responses During a High-Altitude Trek: A Pilot Study Comparing Italian Trekkers to Nepalese Porters.Frontiers in physiology · 2021Article
- Baroreflex Modulation During Acute High-Altitude Exposure in Rats.Frontiers in physiology · 2020Article
- Recruitment of non-perfused sublingual capillaries increases microcirculatory oxygen extraction capacity throughout ascent to 7126 m.The Journal of physiology · 2019Article
- Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia.Physiological reports · 2018Article
- Altitude exposure and increased heart rate: the role of the parasympathetic nervous system.The Journal of physiology · 2017Article
- Response to: Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema".Mediators of inflammationArticle
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsHeart rate is increased in chronic hypoxia and we tested whether this is the result of increased sympathetic nervous activity, reduced parasympathetic nervous activity, or a non-autonomic mechanism. In seven lowlanders, heart rate was measured at sea level and after 2 weeks at high altitude after individual and combined pharmacological inhibition of sympathetic and/or parasympathetic control of the heart. Inhibition of parasympathetic control of the heart alone or in combination with inhibition of sympathetic control abolished the high altitude-induced increase in heart rate. Inhibition of sympathetic control of the heart alone did not prevent the high altitude-induced increase in heart rate. These results indicate that a reduced parasympathetic nervous activity is the main mechanism underlying the elevated heart rate in chronic hypoxia. ABSTRACT: Chronic hypoxia increases resting heart rate (HR), but the underlying mechanism remains incompletely understood. We investigated the relative contributions of the sympathetic and parasympathetic nervous systems, along with potential non-autonomic mechanisms, by individual and combined pharmacological inhibition of muscarinic and/or β-adrenergic receptors. In seven healthy lowlanders, resting HR was determined at sea level (SL) and after 15-18 days of exposure to 3454 m high altitude (HA) without drug intervention (control, CONT) as well as after intravenous administration of either propranolol (PROP), or glycopyrrolate (GLYC), or PROP and GLYC in combination (PROP+GLYC). Circulating noradrenaline concentration increased from 0.9 ± 0.4 nmol l
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.