Evidence map›Paper›PMID 27966069›Full record

ArticleMolecular imaging and biology2017

ImmunoPET Imaging of Murine CD4

Amanda C Freise, Kirstin A Zettlitz, Felix B Salazar, Xiang Lu, Richard Tavaré, Anna M Wu

Abstract read
In one paragraph

Article in Molecular imaging and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Reengineered Anti-CD4 Cys-diabody Variants forMolecular imaging and biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Advances in PET imaging of cancer.Nature reviews. Cancer · 2023
    Review
  8. Immunomodulatory effect of locoregional therapy in the tumor microenvironment.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
  9. Quantitative PET imaging of the CD4 pool in nonhuman primates.European journal of nuclear medicine and molecular imaging · 2022
    Article
  10. Review
  11. Development of aEJNMMI research · 2022
    Article
  12. Review
  13. Molecular imaging to support cancer immunotherapy.Journal for immunotherapy of cancer · 2022
    Review
  14. Noninvasive Imaging of CD4+ T Cells in Humanized Mice.Molecular cancer therapeutics · 2022
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amanda C FreiseDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 570 Westwood Plaza, CNSI, PO Box 951770, Los Angeles, CA, 90095-1770, USA.
Kirstin A ZettlitzDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 570 Westwood Plaza, CNSI, PO Box 951770, Los Angeles, CA, 90095-1770, USA.
Felix B SalazarDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 570 Westwood Plaza, CNSI, PO Box 951770, Los Angeles, CA, 90095-1770, USA.
Xiang LuDepartment of Internal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Richard TavaréDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 570 Westwood Plaza, CNSI, PO Box 951770, Los Angeles, CA, 90095-1770, USA. richard.tavare@regeneron.com.
Anna M WuDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, 570 Westwood Plaza, CNSI, PO Box 951770, Los Angeles, CA, 90095-1770, USA. awu@mednet.ucla.edu.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
UCLA Scholars in Oncologic Molecular lmaging (SOMI)R25CA098010 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PHELPS, MICHAEL E · 2003 to 2013
$5.0M
In vivo imaging of T Cells using engineered antibodies and PETR21AI114255 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, ANNA M · 2014 to 2015
$424k
(PQC4) Imaging CD8 T Cells In Tumor Immunotherapy By ImmunopetR21CA190044 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, ANNA M · 2014 to 2015
$368k
NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA016042NCI NIH HHS R21 CA190044NCI NIH HHS R25 CA098010NIAID NIH HHS P30 AI028697NIAID NIH HHS R21 AI114255
6 · The paper itself

Abstract

purposeMolecular imaging of CD4 PROCEDURES: The effect of protein dose on image contrast (lymphoid tissue-to-muscle ratio) was assessed by administering different amounts of

resultsFor immunoPET imaging, the lowest protein dose of 2 μg of

conclusionsLow-dose GK1.5 cDb yields high-contrast immunoPET images with minimal effects on T cell biology in vitro and in vivo and may be a useful tool for investigating CD4

Indexed as

Positron-Emission TomographyAnimalsAntibodiesAntibody AffinityAntibody SpecificityCD4 AntigensCD4-Positive T-LymphocytesCell ProliferationCysteineCytokinesFemaleLymphoid TissueMice, Inbred C57BLTissue DistributionAntibodiesCD4 AntigensCysteineCytokinesAntibody engineeringCD4DiabodyImmunoPETLymphocytesPositron emission tomographyT cell functionT cellsZirconium-89

Identifiers

PMID27966069
PMCPMC5524218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.