ReviewAsthma research and practice2015
Asthma and obesity: mechanisms and clinical implications.
Review in Asthma research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of dietary interventions in managing pediatric gastroesophageal reflux disease: a comprehensive systematic review.European journal of medical research · 2025Pooled it
- Risk factors for asthma exacerbations during pregnancy: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Asthma control status in pregnancy, body mass index, and maternal vitamin D levels.The Journal of allergy and clinical immunology · 2017Trial
- Article
- The Impact of BMI on the Effect of Biologic Agents for Severe Asthma.Pulmonary therapy · 2026Review
- An Observational Study of the Role of Adiponectin and Vitamin D in Pediatric Asthma and Obesity.Children (Basel, Switzerland) · 2026Article
- Asthma prevalence, associated factors and role of adverse childhood experiences among school-going adolescents: the national School Health Survey in Togo (SHeST-study).BMJ open respiratory research · 2026Article
- Management of Patients With Comorbid Asthma and Obesity: A Large Language Model Evaluation of Clinical Documentation.The journal of allergy and clinical immunology. In practice · 2026Article
- Mechanistic advances in the regulation of asthma by different exercise modalities: an integrative perspective on exercise load characteristics and asthma heterogeneity.Frontiers in physiology · 2026Review
- Associations Between Metabolic Risk Factors and Lung Function Among Adults in Northern Thailand: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Association between the Body Roundness Index and spirometric parameters among U.S. Adolescents from NHANES 2007-2012.BMC pulmonary medicine · 2025Article
- Review
- Association between BMI and asthma in adults over 45 years of age: analysis of Global Burden of Disease 2021, China Health and Retirement Longitudinal Study, and National Health and Nutrition Examination Survey data.EClinicalMedicine · 2025Article
- Association of relative fat mass with asthma: inflammatory markers as potential mediators.Lipids in health and disease · 2025Article
- Article
- Associations between leisure sedentary behaviors, physical activity, and chronic respiratory diseases: a Mendelian randomization study.Archives of medical science : AMS · 2025Article
- Prevalence of Obesity and Its Associated Comorbidities in Adults with Asthma: A Single-Center Study in Saudi Arabia.Medicina (Kaunas, Lithuania) · 2024Article
- The relationship between cardiometabolic index and pulmonary function among U.S. adults: insights from the National Health and Nutrition Examination Survey (2007-2012).Lipids in health and disease · 2024Article
- Factors affecting asthma control in pregnancy: A cross-sectional study.Pakistan journal of medical sciences · 2024Article
- Obesity Enhances Non-Th2 Airway Inflammation in a Murine Model of Allergic Asthma.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is the most common asthma co-morbidity; it has been associated with increased risk for asthma exacerbations, worse respiratory symptoms and poor control. The exact mechanisms remain elusive and are probably multifactorial, stemming from mechanical alterations of the airways and lung parenchyma, to systemic and airway inflammatory and metabolic dysregulation that adversely influences lung function and or response to therapy. However, the fact that not every obese asthmatic is equally affected by weight gain highlights the many challenges and complexities in understanding this association. The factors that determine susceptibility may not depend on being obese alone, but rather the interactions with other phenotypical characteristics, such as age of asthma onset, gender and race to name a few. Inability to account for asthma phenotypes that are differentially affected by increasing body mass index (BMI) may contribute to the lack of consistent results across studies. This review will provide a succinct summary of obesity-related mechanisms and the clinical impact on asthma including highlights on recent progress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.