Evidence map›Paper›PMID 27965669›Full record

ArticleFrontiers in immunology2016

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases.

Nicole Schäfer, Antje Grosche, Joerg Reinders, Stefanie M Hauck, Richard B Pouw, Taco W Kuijpers, Diana Wouters, Boris Ehrenstein, Volker Enzmann, Peter F Zipfel and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. TheOphthalmology science · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The human factor H protein family - an update.Frontiers in immunology · 2024
    Review
  8. Alternative pathway diagnostics.Immunological reviews · 2023
    Review
  9. PathogenicInfection and immunity · 2022
    Article
  10. The OSE complotype and its clinical potential.Frontiers in immunology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Journal of the American Society of Nephrology : JASN · 2020
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Nicole SchäferDepartment of Ophthalmology, University Hospital Regensburg , Regensburg , Germany.
Antje GroscheInstitute of Human Genetics, University of Regensburg , Regensburg , Germany.
Joerg ReindersInstitute of Functional Genomics, University of Regensburg , Regensburg , Germany.
Stefanie M HauckResearch Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH) , Neuherberg , Germany.
Richard B PouwDepartment of Immunopathology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam , Amsterdam , Netherlands.
Taco W KuijpersDepartment of Pediatric Hematology, Immunology and Infectious Diseases, Academic Medical Center, Emma Children's Hospital, Amsterdam, Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Diana WoutersDepartment of Immunopathology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam , Amsterdam , Netherlands.
Boris EhrensteinKlinik und Poliklinik für Rheumatologie und Klinische Immunologie, Asklepios Klinikum Bad Abbach , Bad Abbach , Germany.
Volker EnzmannDepartment of Ophthalmology, Inselspital, University of Bern , Bern , Switzerland.
Peter F ZipfelDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany; Friedrich Schiller University, Jena, Germany.
Christine SkerkaDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology , Jena , Germany.
Diana PaulyDepartment of Ophthalmology, University Hospital Regensburg , Regensburg , Germany.
Academic Medical Center · NLUniversity Hospital Regensburg · DEUniversity of Regensburg · DEAsklepios Kliniken Bad Abbach · DEFriedrich Schiller University Jena · DEHelmholtz Zentrum München · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DESanquin · NLUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous

Indexed as

FH competitionFHR-3/CFHR3immune therapymicroglia/macrophageretinal degenerationrheumatic diseasespecific antibody

Identifiers

PMID27965669
PMCPMC5124756
OpenAlexW2558676182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.