ArticleFrontiers in neurology2016
RU486 Mitigates Hippocampal Pathology Following Status Epilepticus.
Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of Phenosanic Acid in Rat Seizure Models.International journal of molecular sciences · 2025Article
- Early life stress influences epilepsy outcomes in mice.Epilepsy & behavior : E&B · 2025Article
- Hypothalamic-Pituitary-Adrenal Axis and Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2024Review
- Effect of glucocorticoid blockade on inflammatory responses to acute sleep fragmentation in male mice.PeerJ · 2024Article
- The role of cortisol in immunosuppression in subarachnoid haemorrhage.European journal of medical research · 2023Article
- Hippocampal glucocorticoid receptors modulate status epilepticus severity.Neurobiology of disease · 2023Article
- Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.Journal of molecular neuroscience : MN · 2022Article
- Mechanisms of Psychiatric Comorbidities in Epilepsy.Current topics in behavioral neurosciences · 2022Article
- The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus.Experimental neurology · 2021Article
- Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPPOxidative medicine and cellular longevity · 2020Article
- Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy.Drug discovery today · 2020Review
- Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors.Epilepsy & behavior : E&B · 2018Article
- Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Status epilepticus (SE) induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led to the hypothesis that HPA axis dysfunction may exacerbate SE-induced brain injury. To test this hypothesis, we used the mouse pilocarpine model of epilepsy to determine whether use of the glucocorticoid receptor antagonist RU486 can attenuate hippocampal pathology following SE. Excess glucocorticoid secretion was evident 1 day after SE in the mice, preceding the development of spontaneous seizures (which can take weeks to develop). RU486 treatment blocked the SE-associated elevation of glucocorticoid levels in pilocarpine-treated mice. RU486 treatment also mitigated the development of hippocampal pathologies induced by SE, reducing loss of hilar mossy cells and limiting pathological cell proliferation in the dentate hilus. Mossy cell loss and accumulation of ectopic hilar cells are positively correlated with epilepsy severity, suggesting that early treatment with glucocorticoid antagonists could have anti-epileptogenic effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.