ArticleFrontiers in neurology2016
Dynamic Changes in Spectral and Spatial Signatures of High Frequency Oscillations in Rat Hippocampi during Epileptogenesis in Acute and Chronic Stages.
Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals
Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats.Experimental brain research · 2023Article
- Complexity-based graph convolutional neural network for epilepsy diagnosis in normal, acute, and chronic stages.Frontiers in computational neuroscience · 2023Article
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Anticonvulsant Effect of Carbenoxolone on Chronic Epileptic Rats and Its Mechanism Related to Connexin and High-Frequency Oscillations.Frontiers in molecular neuroscience · 2022Article
- Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Application of High-Frequency Oscillations on Scalp EEG in Infant Spasm: A Prospective Controlled Study.Frontiers in human neuroscience · 2021Article
- Catalpol Exerts an Anti-Epilepticus Effect, Possibly by Regulating the Nrf2-Keap1-ARE Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- A new comorbidity model and the common pathological mechanisms of migraine and epilepsy.American journal of translational research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze spectral and spatial signatures of high frequency oscillations (HFOs), which include ripples and fast ripples (FRs, >200 Hz) by quantitatively assessing average and peak spectral power in a rat model of different stages of epileptogenesis.
methodsThe lithium-pilocarpine model of temporal lobe epilepsy was used. The acute phase of epilepsy was assessed by recording intracranial electroencephalography (EEG) activity for 1 day after status epilepticus (SE). The chronic phase of epilepsy, including spontaneous recurrent seizures (SRSs), was assessed by recording EEG activity for 28 days after SE. Average and peak spectral power of five frequency bands of EEG signals in CA1, CA3, and DG regions of the hippocampus were analyzed with wavelet and digital filter.
resultsFRs occurred in the hippocampus in the animal model. Significant dynamic changes in the spectral power of FRS were identified in CA1 and CA3. The average spectral power of ripples increased at 20 min before SE ( SIGNIFICANCE: The spectral power of HFOs may be utilized to distinguish between normal and pathologic HFOs. Ictal average and peak spectral power of FRs were two parameters for predicting acute epileptic seizures, which could be used as a new quantitative biomarker and early warning marker of seizure. Changes in interictal HFOs power in the hippocampus at the chronic stage may be not related to seizure occurrence.
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