Evidence map›Paper›PMID 27965560›Full record

ReviewFrontiers in human neuroscience2016

Ketamine: 50 Years of Modulating the Mind.

Linda Li, Phillip E Vlisides

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 164 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 9 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03525912 nacompletednot on this mapstarted 2017, after this paper: background citation

Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions: a Prospective Study

TypeinterventionalSponsorUniversidad de AntioquiaRan2017 to 2018Enrolled101ConditionsPain, Postoperative, Ketamine Adverse ReactionArmsKetamine
NCT04134052 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of Regional Anesthesia and Sedation With Ketamine Versus Regional Anesthesia and Sedation With Midazolam in Cognitive Function in Patients Over 60 Years of Age in Elective Surgery at 3 Months of Postoperative Follow-up

TypeinterventionalSponsorUniversidad de ColimaRan2021 to 2021Enrolled68ConditionsCognitive DysfunctionArmsketamine sedation versus midazolam sedation
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 9 syntheses or guidelines pooled it, 357 citations in OpenAlex.

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  6. Ketamine treatment for refractory anxiety: A systematic review.British journal of clinical pharmacology · 2022
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  16. [Application of low-dose esmolamine in general anesthesia in pediatric surgeries].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Linda LiDepartment of Internal Medicine, St. Joseph Mercy Hospital Ann Arbor, MI, USA.
Phillip E VlisidesDepartment of Anesthesiology, University of Michigan Medical School Ann Arbor, MI, USA.
Trinity Health Ann Arbor Hospital · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, ketamine's effects on the central nervous system remain incompletely understood. Investigators have leveraged the unique characteristics of ketamine to explore the invariant, fundamental mechanisms of anesthetic action. Emerging evidence indicates that ketamine-mediated anesthesia may occur via disruption of corticocortical information transfer in a frontal-to-parietal ("top down") distribution. This proposed mechanism of general anesthesia has since been demonstrated with anesthetics in other pharmacological classes as well. Ketamine remains invaluable to the fields of anesthesiology and critical care medicine, in large part due to its ability to maintain cardiorespiratory stability while providing effective sedation and analgesia. Furthermore, there may be an emerging role for ketamine in treatment of refractory depression and Post-Traumatic Stress Disorder. In this article, we review the history of ketamine, its pharmacology, putative mechanisms of action and current clinical applications.

Indexed as

anesthesiaconsciousnessdepressionfunctional connectivityketamineneuropharmacologypost-traumatic stress disorder

Identifiers

PMID27965560
PMCPMC5126726
OpenAlexW2557879850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.