ReviewFrontiers in neuroscience2016
Impact of Transcranial Direct Current Stimulation (tDCS) on Neuronal Functions.
Review in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-definition Transcranial Direct Current Stimulation (HD-tDCS) as Augmentation Therapy in Late-life Depression (LLD) With Suboptimal Response to Treatment - Double-blinded Randomized Sham-controlled Trial
Real-world Data Collection and Real-world Evidence Clinical Demonstration Study of tDCS for the Treatment of Depression in Perinatal Women
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The influence of a single transcranial direct current stimulation session on physical fitness in healthy subjects: a systematic review.Experimental brain research · 2023Pooled it
- Efficacy of rTMS combined with tDCS in patients with major depressive disorder with anxiety: a randomised, double-blind, sham-controlled study.BMJ mental health · 2025Trial
- Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial.Translational psychiatry · 2024Trial
- Effects of anodal tDCS on resting state eeg power and motor function in acute stroke: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2024Trial
- The Effects of Transcranial Direct Current Stimulation on Depression, Anxiety, and Stress in Patients with Epilepsy: A Randomized Clinical Trial.Iranian journal of medical sciences · 2021Trial
- Beyond physiotherapy and pharmacological treatment for fibromyalgia syndrome: tailored tACS as a new therapeutic tool.European archives of psychiatry and clinical neuroscience · 2021Trial
- Trial
- Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study.Brain stimulationTrial
- Neuroplasticity After Stroke: Clinical Evidence and Its Implication for Effective Rehabilitation Strategies.Brain & NeuroRehabilitation · 2026Review
- Clinical and Behavioral Outcomes During 4 Weeks of Home-Based Self-Administered Transcranial Direct Current Stimulation in Perinatal Women With Depressive Symptoms: Open-Label Exploratory Pilot Study.JMIR formative research · 2026Article
- Anodal Transcranial Direct Current Stimulation as an Adjunct to Physiotherapy in Lacunar Stroke.Cureus · 2026Article
- Long-term use of tDCS-clinical and ethical considerations.Frontiers in human neuroscience · 2026Article
- From Immediate Impact to Enduring Change: A Transcriptomic Comparison of tDCS's Temporal Effects and Its Long-Term Equivalence with TMS.International journal of molecular sciences · 2025Article
- Non-pharmacological therapeutic paradigms in stress-induced depression: from novel therapeutic perspective with focus on cell-based strategies.Acta neuropsychiatrica · 2025Review
- Navigating the depths: A comprehensive narrative review on depression in people with epilepsy.Heliyon · 2025Review
- Cathodal tDCS and robotic therapy for upper limb rehabilitation in chronic stroke: a randomized controlled trial.Frontiers in neurology · 2025Article
- Transcranial Direct Current Stimulation and Mindfulness for Cognitive and Mood Recovery in Stroke Survivors: A Pilot Randomized Controlled Study.Stroke research and treatment · 2025Article
- Article
- The safety and feasibility of transcranial direct current stimulation combined with conservative treatment for patients with cervicogenic headaches: A double-blinded randomized control study protocol.Contemporary clinical trials communications · 2024Article
- The effect of transcranial Direct Current Stimulation on the Iowa Gambling Task: a scoping review.Frontiers in psychology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, modulates neuronal excitability by the application of a small electrical current. The low cost and ease of the technique has driven interest in potential clinical applications. However, outcomes are highly sensitive to stimulation parameters, leading to difficulty maximizing the technique's effectiveness. Although reversing the polarity of stimulation often causes opposite effects, this is not always the case. Effective clinical application will require an understanding of how tDCS works; how it modulates a neuron; how it affects the local network; and how it alters inter-network signaling. We have summarized what is known regarding the mechanisms of tDCS from sub-cellular processing to circuit level communication with a particular focus on what can be learned from the polarity specificity of the effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.