ArticleJournal of leukocyte biology2017
Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases.Acta pharmaceutica Sinica. B · 2025Review
- CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy.Metabolic brain disease · 2024Article
- What's the Catch? The Significance of Catch Bonds in T Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- CD47-Dependent Regulation of Immune Checkpoint Gene Expression and MYCN mRNA Splicing in Murine CD8 and Jurkat T Cells.International journal of molecular sciences · 2023Article
- Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.Immunity · 2022Article
- Loss of CD47 alters CD8+ T cell activationOncoimmunology · 2022Article
- SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.PloS one · 2022Article
- CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE.JCI insight · 2021Article
- CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation.Frontiers in immunology · 2021Article
- Growth differentiation factor 15 is increased in stable MS.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα-CD47 innate immune checkpoint.Journal for immunotherapy of cancer · 2019Article
- Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Veronica AzcutiaCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ribal BassilAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jan M HerterCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Daniel EngelbertsenCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Gail NewtonCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Anu AutioCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Tanya MayadasCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Andrew H LichtmanCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Samia J KhouryAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Charles A ParkosDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Wassim ElyamanAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; elyaman@rics.bwh.harvard.edu.
Francis W LuscinskasCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; fluscinskas@partners.org.
Harvard University · USBrigham and Women's Hospital · USUniversity of Michigan–Ann Arbor · US
Funding
Intestinal Inflammation: Signaling proteins and the rate of PMN transmigrationR01DK079392 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2007 to 2025
$7.2MNeutrophil Interactions with Intestinal Epithelial CellsR01DK072564 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2005 to 2020
$6.5MStructure-Function Studies on Intestinal Epithelial JAMR01DK061379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2002 to 2021
$6.3MRegulation of T Cell Responses in AtherosclerosisR01HL087282 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LICHTMAN, ANDREW H · 2007 to 2015
$4.0MCD47 Regulation of Leukocyte Integrins during Leukocyte TraffickingR01HL125780 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LUSCINSKAS, FRANCIS W. · 2016 to 2019
$2.3MCytoglobin: A stress-responsive hemoprotein modulating cardiomyocyte survivalR01HL102478 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MAMMEN, PRADEEP P.A. · 2012 to 2016
$2.0MImpact of IFN-gamma on Neural Stem Cell Repair Potential in EAER01AI071448 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHOURY, SAMIA J. · 2007 to 2010
$1.4MNeural Stem Cells and Regulatory T CellsR56AI093838 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHOURY, SAMIA J. · 2012 to 2012
$407kNHLBI NIH HHS R01 HL087282NHLBI NIH HHS R01 HL102478NHLBI NIH HHS R01 HL125780NIAID NIH HHS R01 AI071448NIAID NIH HHS R56 AI093838NIDDK NIH HHS R01 DK061379NIDDK NIH HHS R01 DK072564NIDDK NIH HHS R01 DK079392
Abstract
CD47 is known to play an important role in CD4
Indexed as
Adoptive TransferAnimalsAntibodies, MonoclonalAntigen PresentationCD28 AntigensCD47 AntigenCD4-Positive T-LymphocytesCell AdhesionCell ProliferationChemokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunizationIntegrin alpha4beta1Intercellular Adhesion Molecule-1Antibodies, MonoclonalCD28 AntigensCD47 AntigenChemokinesIntegrin alpha4beta1Intercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1Myelin-Oligodendrocyte GlycoproteinReceptors, Antigen, T-CellVascular Cell Adhesion Molecule-1autoimmuneneuroinflammationTCR activationT lymphocytes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.