Evidence map›Paper›PMID 27965295›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2017

DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.

Devin C Koestler, Joseph Usset, Brock C Christensen, Carmen J Marsit, Margaret R Karagas, Karl T Kelsey, John K Wiencke

Abstract readValidation Study
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
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  8. Observational
  9. Article
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  11. ConstitutionalHuman mutation · 2024
    Review
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  15. Article
  16. Review
  17. Hypermethylation ofMolecular therapy. Nucleic acids · 2022
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Devin C KoestlerDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas. dkoestler@kumc.edu.
Joseph UssetDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas.
Brock C ChristensenDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon New Hampshire.
Carmen J MarsitDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon New Hampshire.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon New Hampshire.
Karl T KelseyDepartment of Epidemiology, Brown University, Providence, Rhode Island.
John K WienckeDepartment of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John A Stanford · 2012 to 2026
$63.0M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2022
$23.7M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
NONMELANOMA SKIN CANCER IN NEW HAMPSHIRER01CA057494 · NCI · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1993 to 2015
$10.9M
Training Program for Quantitative Population Sciences in CancerR25CA134286 · NCI · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA, TOSTESON, TOR D · 2009 to 2018
$3.0M
MicroRNA related genetic variation and head and neck cancerR01DE022772 · NIDCR · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2016
$2.7M
Heartland Institute for Clinical and Translational ResearchKL2TR000119 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$2.5M
Heartland Institute for Clinical and Translational ResearchKL2RR033177 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2011 to 2011
$653k
Heartland Institute for Clinical and Translational ResearchTL1TR000120 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$549k
NCATS NIH HHS KL2 TR000119NCATS NIH HHS TL1 TR000120NCI NIH HHS P30 CA023108NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA057494NCI NIH HHS R25 CA134286NCRR NIH HHS KL2 RR033177NIDCR NIH HHS R01 DE022772NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM104416
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationLeukocytesNeutrophilsAdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsCase-Control StudiesEpigenesis, GeneticFemaleHead and Neck NeoplasmsHumansInflammationLymphocyte CountMaleBiomarkers, Tumor

Identifiers

PMID27965295
PMCPMC5336518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.