ArticleBone & joint research2016
The use of rats and mice as animal models in ex vivo bone growth and development studies.
Article in Bone & joint research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bone physiological adaptations to whole-body vibration in mouse models: A Systematic Review.PloS one · 2026Pooled it
- The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review.Tissue engineering. Part B, Reviews · 2023Pooled it
- Ex Vivo Model Systems of Cancer-Bone Cell Interactions.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Animal models for understanding the mechanisms of malnutrition: a literature review.Frontiers in nutrition · 2025Review
- Advances in experimental bladder models: bridging the gap between in vitro and in vivo approaches for investigating urinary tract infections.BMC urology · 2024Review
- Senescent cells: A therapeutic target for osteoporosis.Cell proliferation · 2022Review
- Roles of Sodium Hydrogen Exchanger (NHE1) and Anion Exchanger (AE2) across Chondrocytes Plasma Membrane during Longitudinal Bone Growth.Membranes · 2022Article
- Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980-2020.Heliyon · 2022Review
- 3D Bioprinted Scaffolds for Bone Tissue Engineering: State-Of-The-Art and Emerging Technologies.Frontiers in bioengineering and biotechnology · 2022Review
- Differentially expressed genes in the femur cartilage transcriptome clarify the understanding of femoral head separation in chickens.Scientific reports · 2021Article
- Jellyfish Collagen: A Biocompatible Collagen Source for 3D Scaffold Fabrication and Enhanced Chondrogenicity.Marine drugs · 2021Article
- Ex vivo Bone Models and Their Potential in Preclinical Evaluation.Current osteoporosis reports · 2021Review
- Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models.Archives of toxicology · 2020Review
- Rational design of hydrogels to enhance osteogenic potential.Chemistry of materials : a publication of the American Chemical Society · 2020Article
- Trends in Bone Metastasis Modeling.Cancers · 2020Review
- Article
- Ex Vivo Organ Cultures as Models to Study Bone Biology.JBMR plus · 2020Review
- Pigment epithelium-derived factor (PEDF) reduced expression and synthesis of SOST/sclerostin in bone explant cultures: implication of PEDF-osteocyte gene regulation in vivo.Journal of bone and mineral metabolism · 2019Article
- Postnatal ex vivo rat model for longitudinal bone growth investigations.Animal models and experimental medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led to the evolution of an ex vivo model system which partially or completely surmounted some of the constraints faced in an in vivo model system. The ex vivo rodent bone culture system has been used to elucidate the understanding of skeletal physiology and pathophysiology for more than 90 years. This review attempts to provide a brief summary of the historical evolution of the rodent bone culture system with emphasis on the strengths and limitations of the model. It encompasses the frequency of use of rats and mice for ex vivo bone studies, nutritional requirements in ex vivo bone growth and emerging developments and technologies. This compilation of information could assist researchers in the field of regenerative medicine and bone tissue engineering towards a better understanding of skeletal growth and development for application in general clinical medicine.Cite this article: A. A. Abubakar, M. M. Noordin, T. I. Azmi, U. Kaka, M. Y. Loqman. The use of rats and mice as animal models in ex vivo bone growth and development studies. Bone Joint Res 2016;5:610-618. DOI: 10.1302/2046-3758.512.BJR-2016-0102.R2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.