ArticleVirus research2017
Genome analysis of canine astroviruses reveals genetic heterogeneity and suggests possible inter-species transmission.
Article in Virus research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Evolutionary and phylogenetic insights from global canine astrovirus genomes.Archives of virology · 2026Article
- Monitoring and characterization of canine and feline astroviruses in domestic dogs and cats in Thailand.Scientific reports · 2025Article
- Metatranscriptomic identification of novel RNA viruses from raccoon dog (Nyctereutes procyonoides) feces in Japan.Scientific reports · 2025Article
- Genetic diversity of astroviruses detected in wild aquatic birds in Hong Kong.Virology journal · 2024Article
- First Report on the Molecular Detection of Canine Astrovirus (CaAstV) in Dogs with Gastrointestinal Disease in Ecuador Using a Fast and Sensitive RT-qPCR Assay Based on SYBR GreenVeterinary sciences · 2024Article
- Molecular characterization and lineage analysis of canine astrovirus strains from dogs with gastrointestinal disease in Ecuador based on ORF-2 gene analysis.Frontiers in veterinary science · 2024Article
- Genetic characterization of canine astrovirus in non-diarrhea dogs and diarrhea dogs in Vietnam and Thailand reveals the presence of a unique lineage.Frontiers in veterinary science · 2023Article
- First report of canine Astrovirus and Sapovirus in Greece, hosting both asymptomatic and gastroenteritis symptomatic dogs.Virology journal · 2022Article
- Molecular survey of parvovirus, astrovirus, coronavirus, and calicivirus in symptomatic dogs.Veterinary research communications · 2021Article
- Genetic characterization and phylogenetic analysis of feline astrovirus from Anhui province in eastern China.3 Biotech · 2020Article
- Molecular characterization of canine astrovirus, vesivirus and circovirus, isolated from diarrheic dogs in Turkey.Iranian journal of veterinary research · 2020Article
- Phylogenetic Analysis of LedniceMicroorganisms · 2019Article
- Detection and characterisation of canine astrovirus, canine parvovirus and canine papillomavirus in puppies using next generation sequencing.Scientific reports · 2019Article
- Detection and phylogenetic characterization of astroviruses in insectivorous bats from Central-Southern Italy.Zoonoses and public health · 2018Article
- Mamastrovirus 5 detected in a crab-eating fox (Cerdocyon thous): Expanding wildlife host range of astroviruses.Comparative immunology, microbiology and infectious diseases · 2018Article
- New viruses associated with canine gastroenteritis.Veterinary journal (London, England : 1997) · 2018Review
- Detection and genetic characterization of canine astroviruses in pet dogs in Guangxi, China.Virology journal · 2017Article
- Detection and genetic characterization of Mamastrovirus 5 from Brazilian dogs.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine astrovirus RNA was detected in the stools of 17/63 (26.9%) samples, using either a broadly reactive consensus RT-PCR for astroviruses or random RT-PCR coupled with massive deep sequencing. The complete or nearly complete genome sequence of five canine astroviruses was reconstructed that allowed mapping the genome organization and to investigate the genetic diversity of these viruses. The genome was about 6.6kb in length and contained three open reading frames (ORFs) flanked by a 5' UTR, and a 3' UTR plus a poly-A tail. ORF1a and ORF1b overlapped by 43 nucleotides while the ORF2 overlapped by 8 nucleotides with the 3' end of ORF1b. Upon genome comparison, four strains (HUN/2012/2, HUN/2012/6, HUN/2012/115, and HUN/2012/135) were more related genetically to each other and to UK canine astroviruses (88-96% nt identity), whilst strain HUN/2012/126 was more divergent (75-76% nt identity). In the ORF1b and ORF2, strains HUN/2012/2, HUN/2012/6, and HUN/2012/135 were related genetically to other canine astroviruses identified formerly in Europe and China, whereas strain HUN/2012/126 was related genetically to a divergent canine astrovirus strain, ITA/2010/Zoid. For one canine astrovirus, HUN/2012/8, only a 3.2kb portion of the genome, at the 3' end, could be determined. Interestingly, this strain possessed unique genetic signatures (including a longer ORF1b/ORF2 overlap and a longer 3'UTR) and it was divergent in both ORF1b and ORF2 from all other canine astroviruses, with the highest nucleotide sequence identity (68% and 63%, respectively) to a mink astrovirus, thus suggesting a possible event of interspecies transmission. The genetic heterogeneity of canine astroviruses may pose a challenge for the diagnostics and for future prophylaxis strategies.
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