ArticleeLife2016
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.
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Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Trial
- A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study.PLoS genetics · 2026Article
- Exercise-mediated regulation of mitochondrial dynamics in aging muscle: implications for mitochondrial diseases.Molecular and cellular biochemistry · 2026Review
- Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature.American journal of human genetics · 2026Article
- Prevalence and predictors of short stature in children aged 3-18 years in Hainan Province, China: a cross-sectional study.Frontiers in pediatrics · 2025Article
- Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Applying an evolutionary mismatch framework to understand disease susceptibility.PLoS biology · 2023Article
- DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.Nature communications · 2023Article
- Intergenerational transmission of height in a historical population: From taller mothers to larger offspring at birth (and as adults).PNAS nexus · 2023Article
- Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels.Genome research · 2022Article
- Your height affects your health: genetic determinants and health-related outcomes in Taiwan.BMC medicine · 2022Article
- Estimating heritability of height without zygosity information for twins under five years in low- and middle-income countries: An application of normal finite mixture distribution models.SSM - population health · 2022Article
- Differences in the number of de novo mutations between individuals are due to small family-specific effects and stochasticity.Genome research · 2021Article
- Gut microbiome heritability is nearly universal but environmentally contingent.Science (New York, N.Y.) · 2021Article
- Identification and characterization of factors associated with short stature and pre-shortness in Chinese preschool-aged children.Endocrine connections · 2021Article
- Identification of contributing predictors for short stature and pre-shortness among 7310 Chinese preschool-aged children.Endocrine · 2021Article
- Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants.Lancet (London, England) · 2020Article
- Article
- Complex Phenotypes: Mechanisms Underlying Variation in Human Stature.Current osteoporosis reports · 2019Review
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Authors and funding
99 authors.
Aline JelenkovicDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Yoon-Mi HurDepartment of Education, Mokpo National University, Jeonnam, South Korea.
Reijo SundDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Yoshie YokoyamaDepartment of Public Health Nursing, Osaka City University, Osaka, Japan.
Sisira H SiribaddanaInstitute of Research & Development, Battaramulla, Sri Lanka.
Matthew HotopfNIHR Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, United Kingdom.
Athula SumathipalaInstitute of Research & Development, Battaramulla, Sri Lanka.
Fruhling RijsdijkMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Qihua TanEpidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Dongfeng ZhangDepartment of Public Health, Qingdao University Medical College, Qingdao, China.
Zengchang PangDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Sari AaltonenDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Kauko HeikkiläDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Sevgi Y ÖncelDepartment of Statistics, Faculty of Arts and Sciences, Kirikkale University, Kirikkale, Turkey.
Fazil AlievFaculty of Business, Karabuk University, Karabuk, Turkey.
Esther RebatoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain.
Adam D TarnokiDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
David L TarnokiDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
Kaare ChristensenThe Danish Twin Registry, University of Southern Denmark, Odense, Denmark.
Axel SkyttheThe Danish Twin Registry, University of Southern Denmark, Odense, Denmark.
Kirsten O KyvikDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Judy L SilbergDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States.
Lindon J EavesDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States.
Hermine H MaesDepartment of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States.
Tessa L CutlerThe Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia.
John L HopperThe Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia.
Juan R OrdoñanaDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Juan F Sánchez-RomeraIMIB-Arrixaca, Murcia, Spain.
Lucia Colodro-CondeDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Wendy CozenDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, United States.
Amie E HwangDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, United States.
Thomas M MackDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, United States.
Joohon SungDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Yun-Mi SongDepartment of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South-Korea.
Sarah YangDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Kayoung LeeDepartment of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, San Diego, United States.
William S KremenDepartment of Psychiatry, University of California, San Diego, San Diego, United States.
Michael J LyonsDepartment of Psychology, Boston University, Boston, United States.
Andreas BusjahnHealthTwiSt GmbH, Berlin, Germany.
Tracy L NelsonDepartment of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, Colorado, United States.
Keith E WhitfieldPsychology and Neuroscience, Duke University, Durham, United States.
Christian KandlerDepartment of Psychology, Bielefeld University, Bielefeld, Germany.
Kerry L JangDepartment of Psychiatry, University of British Columbia, Vancouver, Canada.
Margaret GatzDepartment of Psychology, University of Southern California, Los Angeles, United States.
David A ButlerHealth and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, United States.
Maria A StaziIstituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Corrado FagnaniIstituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Cristina D'IppolitoIstituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Glen E DuncanWashington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, United States.
Dedra BuchwaldWashington State Twin Registry, Washington State University, Seattle, United States.
Catherine A DeromCentre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Robert F VlietinckCentre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Ruth Jf LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Nicholas G MartinGenetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sarah E MedlandGenetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Grant W MontgomeryMolecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Hoe-Uk JeongDepartment of Education, Mokpo National University, Jeonnam, South Korea.
Gary E SwanStanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Ruth KrasnowCenter for Health Sciences, SRI International, Menlo Park, United States.
Patrik Ke MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anna K Dahl-AslanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Tom A McAdamsMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Thalia C EleyMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Alice M GregoryDepartment of Psychology, Goldsmiths, University of London, London, United Kingdom.
Per TyneliusDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Laura A BakerDepartment of Psychology, University of Southern California, Los Angeles, United States.
Catherine TuvbladDepartment of Psychology, University of Southern California, Los Angeles, United States.
Gombojav BayasgalanHealthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Danshiitsoodol NarandalaiHealthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
Genevieve LachanceDepartment of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
Meike BartelsDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Toos Cem van BeijsterveldtDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
S Alexandra BurtMichigan State University, East Lansing, Michigan, United States.
Kelly L KlumpMichigan State University, East Lansing, Michigan, United States.
Jennifer R HarrisNorwegian Institute of Public Health, Oslo, Norway.
Ingunn BrandtNorwegian Institute of Public Health, Oslo, Norway.
Thomas Sevenius NilsenNorwegian Institute of Public Health, Oslo, Norway.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, United States.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, United States.
Shandell PahlenDepartment of Psychology, University of Minnesota, Minneapolis, United States.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, United States.
Jacob V B HjelmborgThe Danish Twin Registry, University of Southern Denmark, Odense, Denmark.
Jack H GoldbergDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, United States.
Yoshinori IwataniOsaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Mikio WatanabeOsaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Chika HondaOsaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Fujio InuiOsaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Finn RasmussenDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Brooke M HuibregtseInstitute for Behavioral Genetics, University of Colorado, Boulder, United States.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Thorkild I A SørensenNovo Nordisk Foundation Centre for Basic Metabolic Research (Section on Metabolic Genetics), University of Copenhagen, Copenhagen, Denmark.
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Karri SilventoinenDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Funding
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MTwin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MThe VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3MUSC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9MTRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUPEL, JAMES W. · 1990 to 2008
$17.5MThe VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8MThe VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7MRISK FACTORS FOR ANTISOCIAL BEHAVIORR01MH058354 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BAKER, LAURA A · 2000 to 2013
$8.5MBuilding a Unique National Community Based Twin RepositoryRC2HL103416 · NHLBI · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 2009 to 2010
$7.7MResearch Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3MThe Effects of Estradiol on Genetic Risk for Disordered Eating During PubertyR01MH092377 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2010 to 2014
$3.4MDNA methylation differences between identical twinsR01ES015150 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, THOMAS MCCULLOCH · 2006 to 2009
$3.1MEuropean Research Council 230374NHLBI NIH HHS RC2 HL103416NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502NIA NIH HHS P01 AG008761NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG050595NIA NIH HHS R21 AG039572NICHD NIH HHS R01 HD010333NICHD NIH HHS R01 HD066040NIDA NIH HHS P60 DA011015NIDA NIH HHS T32 DA017637NIEHS NIH HHS R01 ES015150NIMH NIH HHS R01 MH058354NIMH NIH HHS R01 MH081813NIMH NIH HHS R01 MH092377NIMH NIH HHS R03 MH063851NIMH NIH HHS R21 MH070542
Abstract
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.
Indexed as
Environmental ExposureAdultAgedAged, 80 and overBody HeightCohort StudiesFemaleGlobal HealthHumansMaleMiddle AgedTwinsYoung Adultbirth cohortsCODATwins projectheightheritabilityhumanhuman biologymedicinetwins
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