ArticleGenome biology2016
Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx.
Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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94 citing papers in PubMed, 225 citations in OpenAlex.
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- Assessment of the Thyroid Profile in the Iberian Lynx (Veterinary sciences · 2026Article
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- Genome sequencing uncovers the history of the Russian desman's gradual population decline and contributes to the evolutionary history of Talpidae.BMC ecology and evolution · 2026Article
- Genomic Insights Into the Origin, Decline and Recovery of the Once Critically Endangered Iberian Lynx.Molecular ecology · 2025Review
- Genome Variation in Three Anthophora Bee Species Reflects Divergent Demographic Histories.Molecular ecology · 2025Article
- Parasite-mediated inbreeding depression in wild red deer.Heredity · 2025Article
- Conservation genomics of two endangered buntings reveal genetic diversity before and after severe population declines.BMC biology · 2025Article
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- Assessing simulation-based supervised machine learning for demographic parameter inference from genomic data.Heredity · 2025Article
- The Demographic History of Populations and Genomic Imprinting have Shaped the Transposon Patterns in Arabidopsis lyrata.Molecular biology and evolution · 2025Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
50 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction.
resultsWe generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics. We identify a series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution. We observe drastically reduced rates of weak-to-strong substitutions associated with GC-biased gene conversion and increased rates of fixation of transposable elements. We also find multiple signatures of genetic erosion in the two remnant Iberian lynx populations, including a high frequency of potentially deleterious variants and substitutions, as well as the lowest genome-wide genetic diversity reported so far in any species.
conclusionsThe genomic features observed in the Iberian lynx genome may hamper short- and long-term viability through reduced fitness and adaptive potential. The knowledge and resources developed in this study will boost the research on felid evolution and conservation genomics and will benefit the ongoing conservation and management of this emblematic species.
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