Evidence map›Paper›PMID 27960602›Full record

ArticleOcular immunology and inflammation2018

Use of Immunosuppressive Medications for Treatment of Pediatric Intermediate Uveitis.

Aimee O Hersh, Spencer Cope, John F Bohnsack, Akbar Shakoor, Albert T Vitale

Abstract read
In one paragraph

Article in Ocular immunology and inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aimee O Hersha Division of Rheumatology, Department of Pediatrics , University of Utah School of Medicine , Salt Lake City , Utah , USA.
Spencer Copeb University of Texas San Antonio, Center for Health Sciences , San Antonio , Texas , USA.
John F Bohnsacka Division of Rheumatology, Department of Pediatrics , University of Utah School of Medicine , Salt Lake City , Utah , USA.
Akbar Shakoorc Department of Ophthalmology , John A. Moran Eye Center, University of Utah School of Medicine , Salt Lake City , Utah , USA.
Albert T Vitalec Department of Ophthalmology , John A. Moran Eye Center, University of Utah School of Medicine , Salt Lake City , Utah , USA.
University of Utah · USThe University of Texas at San Antonio · US

Funding

Adult Outcomes of Juvenile Idiopathic ArthritisK23AR066064 · NIAMS · UNIVERSITY OF UTAH · PI HERSH, AIMEE O · 2014 to 2018
$817k
NIAMS NIH HHS K23 AR066064
6 · The paper itself

Abstract

purposeTo describe the treatment and outcomes of a cohort of pediatric intermediate uveitis (IU) patients, with a particular focus on the use of immunomodulatory therapy (IMT).

methodsThe disease course, treatment, and outcomes of 39 pediatric IU patients treated in the Uveitis Clinic at the University of Utah from 1999 to 2012 were reviewed, retrospectively.

resultsMean age at presentation was 7.7 years (SD 3.1). In total, 95% had bilateral involvement. Out of 77 total eyes involved, the most frequent disease complications were ocular hypertension (0.71 events per person year, PPY), cataracts (events PPY = 0.39), and cystoid macular edema (events PPY = 0.33). A total of 20 patients received IMT; 19/20 were tapered off systemic corticosteroids without a uveitis recurrence; 75% of eyes had inactive disease at final follow-up (mean 37 months).

conclusionsThe use of IMT, including biologic therapies, may effectively manage disease inflammation and reduce steroid dosages in pediatric IU patients.

Indexed as

Visual AcuityChildDisease ProgressionFemaleFollow-Up StudiesHumansImmunosuppressive AgentsMaleRetrospective StudiesTreatment OutcomeUveitis, IntermediateImmunosuppressive AgentsImmunosuppressionintermediate uveitispediatrics

Identifiers

PMID27960602
PMCPMC5519449
OpenAlexW2562385411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.