ReviewExpert review of anti-infective therapy2017
Ivermectin: a complimentary weapon against the spread of malaria?
Review in Expert review of anti-infective therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04836299 (Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the Efficacy and Therapeutic Safety of Ivermectin Versus Placebo Associated With Standard of Care Treatment in the Early Phase of Coronavirus Infection), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the Efficacy and Therapeutic Safety of Ivermectin Versus Placebo Associated With Standard of Care Treatment in the Early Phase of Coronavirus Infection (COVID19).
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Acute and prolonged effects of anti-malarial drugs on mitochondrial respiration in atrial cardiomyocytes for cardiac safety evaluation.PloS one · 2026Article
- Outdoor biting by malaria vectors: what are the options for intervention?Malaria journal · 2025Review
- Malaria: past, present, and future.Signal transduction and targeted therapy · 2025Review
- Fipronil prevents transmission of Lyme disease spirochetes.Parasitology · 2024Article
- Association of anthelmintic treatment with malaria prevalence in Rural Sussundenga, Mozambique.Wellcome open research · 2023Article
- Broadening the range of use cases for ivermectin - a review of the evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Review
- Effects of ivermectin treatment of backyard chickens on mosquito dynamics and West Nile virus transmission.PLoS neglected tropical diseases · 2022Article
- From informed consent to adherence: factors influencing involvement in mass drug administration with ivermectin for malaria elimination in The Gambia.Malaria journal · 2021Article
- Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.Frontiers in pharmacology · 2021Article
- Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania.Malaria journal · 2020Article
- Insights into the impact of Ivermectin on some protein aspects linked to Culex pipiens digestion and immunity.Parasitology research · 2020Article
- Optimising systemic insecticide use to improve malaria control.BMJ global health · 2019Article
- Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Drugs in Development for Malaria.Drugs · 2018Review
- Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles.Malaria journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionIvermectin has transformed the treatment of parasitic diseases and led to incommensurable benefits to humans and animals. Ivermectin is effective in treating several neglected infectious diseases and recently it has been shown to reduce malaria parasite transmission. Areas covered: Malaria control strategies could benefit from the addition of ivermectin to interrupt the transmission cycle if it is a long lasting formulation or repeatedly administered. In turn, this will help also to control neglected infectious diseases where the elimination goal has been slower to achieve. Despite the relevance of using ivermectin for integrated and sustained disease control, there are still essential questions that remain to be addressed about safety and practicality. The efficacy in various malaria ecologies and the interaction between control tools, either drugs or insecticides, are also important to assess. Expert commentary: Overlapping distribution of several infectious diseases reveals the benefit of integrating control programs against several infectious diseases into one strategy for cost effectiveness and to reach the elimination goals. The use of ivermectin to control malaria transmission will necessitate development and testing of long-lasting formulations or repeated treatments, and implementation of these treatments with other disease control tools may increase the chance of successful and sustained control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.